Logo - springer
Slogan - springer

Biomedical Sciences - Human Genetics | Environmental Epigenomics in Health and Disease - Epigenetics and Disease Origins

Environmental Epigenomics in Health and Disease

Epigenetics and Disease Origins

Jirtle, Randy L, Tyson, Frederick L. (Eds.)

2013, XV, 302 p. 41 illus., 34 illus. in color.

Available Formats:
eBook
Information

Springer eBooks may be purchased by end-customers only and are sold without copy protection (DRM free). Instead, all eBooks include personalized watermarks. This means you can read the Springer eBooks across numerous devices such as Laptops, eReaders, and tablets.

You can pay for Springer eBooks with Visa, Mastercard, American Express or Paypal.

After the purchase you can directly download the eBook file or read it online in our Springer eBook Reader. Furthermore your eBook will be stored in your MySpringer account. So you can always re-download your eBooks.

 
$149.00

(net) price for USA

ISBN 978-3-642-23380-7

digitally watermarked, no DRM

Included Format: PDF and EPUB

download immediately after purchase


learn more about Springer eBooks

add to marked items

Hardcover
Information

Hardcover version

You can pay for Springer Books with Visa, Mastercard, American Express or Paypal.

Standard shipping is free of charge for individual customers.

 
$189.00

(net) price for USA

ISBN 978-3-642-23379-1

free shipping for individuals worldwide

usually dispatched within 3 to 5 business days


add to marked items

  • Provides evidence that environmental exposures during early development can alter the risk of developing medical conditions
  • Presents epigenetic processes that occur in human embryonic stem cells, as well as in differentiating cells and organs such as the brain, discussing autism, schizophrenia and even sexual dimorphism in the developing brains of males and females.
  • Summarizes the latest epigenetic advances in the understanding of cancer development and progression, with a special focus on DNA methylation¬† alterations and their value in clinical oncology for cancer management

Exposure to environmental toxicants is associated with changes in DNA methylation and gene expression profiles that together can contribute to increased disease susceptibility. The chapters in this volume, Environmental Epigenomics in Health and Disease - Epigenetics and Disease Origins, address a wide range of environmental exposures, such as airborne particulates, cocaine, radiation, tobacco smoke, and xenoestrogens. Particular emphasis is placed on the consequences of environmental exposures during development on epigenetic reprogramming that influences adult disease pathogenesis. Health outcomes associated with these exposures include autoimmune disorders, neurodevelopmental disorders, and cancer. Importantly, dietary supplements and drugs can modify the epigenetic effects induced by these agents, thereby reducing their toxicological impact. The overall purpose of this volume and its companion, Environmental Epigenomics in Health and Disease - Epigenetics and Complex Diseases, is to give readers an overview of how environmental exposures during early development can influence disease formation by disrupting epigenetic processes and developmental programming.

Content Level » Research

Keywords » Agouti mouse - CTCF dysfunction - chromatin switching - endocrine disruptors - environmental aromatic hydrocarbons - environmental exposures - genomic imprinting - imprinted brain - imprintome - memory formation - metastable epialleles

Related subjects » Cancer Research - Human Genetics

Table of contents / Preface / Sample pages 

Popular Content within this publication 

 

Articles

Read this Book on Springerlink

Services for this book

New Book Alert

Get alerted on new Springer publications in the subject area of Human Genetics.