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Biomedical Sciences - Human Genetics | Quantitative Trait Loci (QTL) - Methods and Protocols

Quantitative Trait Loci (QTL)

Methods and Protocols

Series: Methods in Molecular Biology, Vol. 871

Rifkin, Scott A. (Ed.)

2012, XI, 331p. 87 illus., 4 illus. in color.

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  • A practical resource for researchers interested in link between phenotypic and genotypic variation
  • Provides step-by-step detail essentail for reproducible results
  • Contains key notes and implementation advice from the experts

Over the last two decades advances in genotyping technology, and the development of quantitative genetic analytical techniques have made it possible to dissect complex traits and link quantitative variation in traits to allelic variation on chromosomes or quantitative trait loci (QTLs). In Quantitative Trait Loci (QTLs):Methods and Protocols, expert researchers in the field detail methods and techniques that focus on specific components of the entire process of quantitative train loci experiments. These include methods and techniques for the mapping populations, identifying quantitative trait loci, extending the power of quantitative trait locus analysis, and case studies. Written in the highly successful Methods in Molecular Biology™ series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory.


Thorough and intuitive, Quantitative Trait Loci (QTLs):Methods and Protocols aids scientists in the further study of the links between phenotypic and genotypic variation in fields from medicine to agriculture, from molecular biology to evolution to ecology.

Content Level » Professional/practitioner

Keywords » Mendelian traits - agriculture - allelic variation - ecology - genotypic variation - human disease - medicine - molecular biology - phenotypic variation - quantitative trait loci

Related subjects » Human Genetics

Table of contents 

Part I. Setting Up Mapping Populations


1. Backcross Populations and Near Isogenic Lines

Rik Kooke, Erik Wijnker and Joost. J.B. Keurentjes


2. F2 Designs for QTL Analysis

Yuan-Ming Zhang


3. Design and Construction of Recombinant Inbred Lines

Daniel A. Pollard


4. Two Flavors of Bulk Segregant Analysis in Yeast

Maitreya J. Dunham


5. Selecting Markers and Evaluating Coverage

Matthew A. Cleveland and Nader Deeb


Part II. Identifying Quantitative Trait Loci


6. Composite Interval Mapping and Multiple Interval Mapping: Procedures and Guidelines for Using Windows QTL Cartographer

Luciano Da Costa E Silva, Shengchu Wang, and Zhao-Bang Zen


7. Design Database for Quantitative Trait Loci (QTL) Data Warehouse, Data Mining and Meta Analysis

Zhi-Liang Hu, James M Reecy and Xiao-Lin Wu


8. Meta-Analysis of QTL Mapping Experiments

Xiao-Lin Wu and Zhi-Liang Hu


Part III. Extending the Power of Quantitative Train Locus Analysis


9. Using eQTLs to Reconstruct Gene Regulatory Networks

Lin S. Chen


10. Estimation and Interpretation of Genetic Effects with Epistasis using the NOIA Model

José M Álvarez-Castro, Örjan Carlborg and Lars Rönnegård


11. Identifying QTL for Multiple Complex Traits in Experimental Crosses

Samprit Banerjee and Nengjun Yi


12. Functional Mapping of Developmental Processes: Theory, Applications and Prospects

Kiranmoy Das, Zhongwen Huang, Jingyuan Liu, Guifang Fu, Jiahan Li, Yao Li, Chunfa Tong, Junyi Gai and Rongling Wu


13. Statistical Models for Genetic Mapping in Polyploids: Challenges and Opportunities

Jiahan Li, Kiranmoy Das, Guifang Fu, Yao Li, Christian Tobias and Rongling Wu


Part IV. Case Studies


14. eQTL

Lun Li, Xianghua Zhang and Hongyu Zhao


15. Genetic Mapping of Quantitative Trait Loci for Disease-Related Phenotyples

Marcella Devoto and Mario Falchi


16. Quantitative Trait Locus Analysis in Haplodiploid Hymenoptera

Jürgen Gadau, Christof Pietsch, Leo W Beukeboom

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