Overview
- Contributors include scientists who developed the first clinical applications of stem-cell gene therapy for HIV
- Outlines a path for a possible functional cure for HIV
- Comprises a thorough and methodical explanation of the basics of gene therapy
- Includes supplementary material: sn.pub/extras
Part of the book series: SpringerBriefs in Biochemistry and Molecular Biology (BRIEFSBIOCHEM)
Access this book
Tax calculation will be finalised at checkout
Other ways to access
Table of contents (9 chapters)
-
Front Matter
-
Back Matter
Keywords
About this book
This Brief describes the concept and realization of gene therapy for HIV from the unique historic perspective and insight of two pioneers of the clinical applications of stem cell gene therapy for HIV.
Gerhard Bauer applied ribozyme-anti-HIV and other vectors to manufacture clinical grade, HIV-resistant hematopoietic stem cells for the first patients that received stem cell gene therapy for HIV, including the first child in the world and the first fully marrow-ablated HIV infected patient. Joseph Anderson developed the most recent and most potent combination anti-HIV lentiviral vectors and pluripotent stem cell applications for HIV gene therapy and tested these in the appropriate in vitro and vivo models, paving the way for novel HIV gene therapy approaches to possibly cure patients.
In Gene Therapy for HIV, Bauer and Anderson discuss the unique aspects of this therapy, including its limitations and proper safety precautions and outline a path for a possible functional cure for HIV using stem cell gene therapy based on a cure already achieved with a bone marrow stem cell transplantation performed in Germany using donor stem cells with a naturally arising CCR5 mutation. In addition, the Brief provides a thorough and methodical explanation of the basics of gene therapy, gene therapy vector development, in vitro and in vivo models for HIV gene therapy and clinical applications of HIV gene therapy, including Good Manufacturing Practices.
Authors and Affiliations
Bibliographic Information
Book Title: Gene Therapy for HIV
Book Subtitle: From Inception to a Possible Cure
Authors: Gerhard Bauer, Joseph S. Anderson
Series Title: SpringerBriefs in Biochemistry and Molecular Biology
DOI: https://doi.org/10.1007/978-1-4939-0434-1
Publisher: Springer New York, NY
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Gerhard Bauer and Joseph S. Anderson 2014
Softcover ISBN: 978-1-4939-0433-4Published: 08 February 2014
eBook ISBN: 978-1-4939-0434-1Published: 07 February 2014
Series ISSN: 2211-9353
Series E-ISSN: 2211-9361
Edition Number: 1
Number of Pages: VIII, 72
Number of Illustrations: 3 illustrations in colour
Topics: Gene Therapy, Virology, Immunology, Vaccine