Overview
- Editors:
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Struan F.A. Grant
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Children's Hospital of Philadelphia Research Institute, Philadelphia, USA
Comprehensive review of efforts aimed at uncovering genetic variants associated with obesity
Covers breakthroughs in syndromic obesity, including Bardet-Biedl and Prader-Willi syndromes
Reviews Genome-wide Association Studies and effects on obesity research?
Includes supplementary material: sn.pub/extras
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Table of contents (7 chapters)
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Front Matter
Pages i-viii
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- I. Sadaf Farooqi, Stephen O’Rahilly
Pages 23-32
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- Åsa K. Hedman, Cecilia M. Lindgren, Mark I. McCarthy
Pages 33-53
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- Julia Sarah El-Sayed Moustafa, Philippe Froguel
Pages 55-70
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- Bratati Kahali, Elizabeth K. Speliotes
Pages 93-111
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- Stefanie Seehaus, Ulrich Rüther
Pages 113-125
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Back Matter
Pages 127-128
About this book
In the past four years, many genetic loci have been implicated for BMI from the outcomes of genome-wide association studies (GWAS), primarily in adults. Insulin-induced gene 2 (INSIG2) was the first locus to be reported by this method to have a role in obesity but replication attempts have yielded inconsistent outcomes. The identification of the second locus, the fat mass- and obesity-associated gene (FTO), h has been more robustly observed by others. Studies from both FTO knock out and FTO overexpression mouse model support the fact that FTO is directly involved in the regulation of energy intake and metabolism in mice, where the lack of FTO expression leads to leanness while enhanced expression of FTO leads to obesity. Along with numerous other studies, a number of genetic variants have been established robustly in the context of obesity, giving us fresh insights into the pathogenesis of the disease. This book will give a comprehensive overview of efforts aimed at uncovering genetic variants associated with obesity, which have been particularly successful in the past 5 years with the advent of genome-wide association studies (GWAS). This book will cover this state of the art technology and its application to obesity in great detail. Topics covered will include genetics of childhood obesity, genetics of syndromic obesity, copy number variants and extreme obesity, co-morbidities of obesity genetics, and functional follow-up of genetic variants.
Editors and Affiliations
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Children's Hospital of Philadelphia Research Institute, Philadelphia, USA
Struan F.A. Grant
