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Biomedical Sciences - Human Genetics | Epigenetics and Complex Traits

Epigenetics and Complex Traits

Naumova, Anna K., Greenwood, Celia MT (Eds.)

2013, XXII, 341 p. 43 illus., 33 illus. in color.

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  • Focuses on the relationship between epigenetic changes and genetic changes in human disease ​
  • A resource for those working in human genetics to learn of the impact epigenetics has on inheritance    
  • Presents detailed and distinct views on the interplay between complex traits and epigenetics

Epigenetics and Complex Traits provides an overview of basic epigenetic phenomena that influence transmission of genetic traits, including the pivotal roles of epigenetic factors in genome integrity, genetic transmission and phenotypic variation at critical developmental points, interactions between epigenetic marks and genetic variation, as well as a detailed examination of how epigenetic considerations can alter interpretation and analysis of risks for complex traits.

 

Included in this book are several overviews of the impact of inter-individual variation in epigenetic states, from major changes that cause congenital developmental defects to subtle changes and their impact on complex traits. In addition, there are chapters examining the relationship between epigenetic changes and genetic changes in human disease, methods for statistical analysis of epigenetics effects in human disease genetic studies or in population genetics, and a consideration of how epigenetics influences inheritance and analysis of inheritance.

 

Epigenetics and Complex Traits is a  resource for those who are working in mammalian genetics or analysis of human genetic data and are interested in the impact of epigenetics on inheritance. 

                                    

Content Level » Research

Keywords » complex traits - molecular genetics - population genetics

Related subjects » Evolutionary & Developmental Biology - Human Genetics - Life Sciences, Medicine & Health

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