Epigenetics and Complex Traits

1. Front Matter

   Pages i-xxii

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2. Epigenetic Phenomena in the Germ Line and Early Embryonic Development and Their Effects on the Inheritance of Genetic Traits

   1. Front Matter

      Pages 1-1

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   2. Epigenetic Reprogramming in the Mammalian Germline

      • Stéphanie Maupetit-Méhouas, David Nury, Philippe Arnaud

      Pages 3-34

   3. Establishment of Tissue-Specific Epigenetic States During Development

      • Ionel Sandovici

      Pages 35-62

   4. X-Chromosome Inactivation

      • Wendy P. Robinson, Allison M. Cotton, Maria S. Peñaherrera, Samantha B. Peeters, Carolyn J. Brown

      Pages 63-88

   5. Cis- and Trans-Effects Underlying Polar Overdominance at the Callipyge Locus

      • Michel Georges, Haruko Takeda, Huijun Cheng, Xu Xuewen, Tracy Hadfield-Shay, Noelle Cockett et al.

      Pages 89-106

   6. Transgenerational Epigenetic Effects and Complex Inheritance Patterns

      • Anna K. Naumova

      Pages 107-129

   7. Autosomal Monoallelic Expression

      • Virginia Savova, Alexander A. Gimelbrant

      Pages 131-144

3. Epigenetic Variation in Health and Disease

   1. Front Matter

      Pages 145-145

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   2. Recurrent CNVs in the Etiology of Epigenetic Neurodevelopmental Disorders

      • Janine M. LaSalle, Mohammad Saharul Islam

      Pages 147-178

   3. Impact of the Early-Life Environment on the Epigenome and Behavioral Development

      • Benoit Labonté, Gustavo Turecki

      Pages 179-207

   4. Interaction Between Genetics and Epigenetics in Cancer

      • Amanda Ewart Toland

      Pages 209-229

4. Impact of Epigenetics on Complex Trait Genetics and Analysis

   1. Front Matter

      Pages 231-231

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   2. Epigenetic Variation, Phenotypic Heritability, and Evolution

      • Robert E. Furrow, Freddy B. Christiansen, Marcus W. Feldman

      Pages 233-246

   3. Statistical Approaches for Detecting Transgenerational Genetic Effects in Humans

      • Janet S. Sinsheimer, Michelle M. Creek

      Pages 247-264

   4. Transmission Ratio Distortion: A Neglected Phenomenon with Many Consequences in Genetic Analysis and Population Genetics

      • Aurélie Labbe, Lam Opal Huang, Claire Infante-Rivard

      Pages 265-285

   5. Epigenome-Wide Association Studies: Potential Insights into Human Disease

      • Christopher G. Bell

      Pages 287-317

   6. Analytical Considerations for Epigenome-Wide Association Scans of Complex Traits

      • Jordana T. Bell

      Pages 319-338

5. Back Matter

   Pages 339-341

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This book will provide an overview of basic epigenetic phenomena; interaction between epigenetic and genetic factors; and the influence of epigenetic factors on inheritance. Epigenetic states may contribute to the penetrance of genetic polymorphisms or mutations and thereby modify inheritance patterns. This may result in non‐Mendelian inheritance of genetic traits such as observed in common human disease. The relationship between epigenetics and genetics, however, has not been comprehensively summarized yet. The topic is being more and more appreciated lately due to considerable advances in genomic and epigenomic approaches to study the origins of human disease.   The editors will focus not only on describing epigenetic characteristics, mechanisms and results, but also on how considerations of epigenetics can alter interpretation and analysis of risks for complex traits. This book will be a resource for those who have been working in human genetics or analysis of human genetic data and are studying the impact of epigenetics on inheritance. An overview will be given of the impacts of inter‐individual variation in epigenetic states from major changes (errors in genomic imprinting) that cause congenital developmental defects to subtle changes and their impact on complex traits. The editors will discuss the relationship between epigenetic changes and genetic changes in human disease. Several chapters will also focus on statistical analysis of epigenetics effects, either in human disease genetic studies, or in population genetics. ​  

• complex traits
• molecular genetics
• population genetics

• Departments of Obstetrics and Gynecology and Human Genetics, McGill University, Montreal, Canada

  Anna K. Naumova

• Lady Davis Institute for Medical Research Centre for Clinical Epidemiology, Jewish General Hospital, Montreal, Canada

  Celia M.T. Greenwood

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