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Biomedical Sciences - Human Genetics | Stearoyl-CoA Desaturase Genes in Lipid Metabolism

Stearoyl-CoA Desaturase Genes in Lipid Metabolism

Ntambi, James M. (Ed.)

2013, XI, 239 p. 42 illus., 24 illus. in color.

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  • First book to focus on SCD Genes in Lipid Metabolism
  • This book includes chapters by leading researchers on SCD Genes in the brain, heart, muscle, liver, metabolism, Colitis, and more​
  • Gives an overview of the growth of research on the role of the stearoyl-CoA desaturase (SCD) genes in metabolism in different species

James Ntambi has gathered top authors to write about the remarkable growth of research on the role of the stearoyl-CoA desaturase (SCD) genes in metabolism in different species including human. The book shows that beginning with simple cellular models of differentiation a broad and comprehensive analysis of the SCD gene family in a number of species and biological systems has been carried out over the course of the last twenty five years. SCD is a central enzyme in lipid metabolism that synthesizes monounsaturated fatty acids (MUFA) from saturated fatty acid precursors. At first glance, SCD would be considered a housekeeping enzyme because its product oleate is a well-known MUFA that is abundant in many dietary sources and tissue lipids.

A particular highlight in the chapters of the book is that MUFAs may have signaling properties that regulate metabolism. For example, a proper ratio of saturated to MUFA contributes to membrane fluidity, and oleate has also been implicated as a mediator of signal transduction, cellular differentiation and metabolic homeostasis. It is also highlighted that SCD-1 repression mediates the metabolic effects of the hormone leptin. Conditional alleles and corresponding tissue-specific knockout mouse models for many of the SCD gene isorfms have provided a wealth of information on not only tissue-specific fatty acid metabolism but also the key transcription factors that regulate SCD expression under a variety of metabolic and genetic backgrounds. The studies described indicate that control of SCD expression occurs via a series of complex signal transduction schemes making SCD one of the most highly studied lipogenic gene families to date.

Content Level » Research

Keywords » Endocrinology - Gene Regulation - Lipids - Metabolism - SCD Genes

Related subjects » Human Genetics - Internal Medicine - Life Sciences

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