Overview
- Editors:
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James M. Ntambi, Ph.D.
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Departments of Biochemistry and Nutritional Sciences, University of Wisconsin-Madison, Madison, USA
- First book to focus on SCD Genes in Lipid Metabolism
- This book includes chapters by leading researchers on SCD Genes in the brain, heart, muscle, liver, metabolism, Colitis, and more?
- Gives an overview of the growth of research on the role of the stearoyl-CoA desaturase (SCD) genes in metabolism in different species
- Includes supplementary material: sn.pub/extras
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Table of contents (15 chapters)
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- David A. Bernlohr, M. Daniel Lane
Pages 1-11
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- Satish Parimoo, Pappas Apostolos
Pages 13-25
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- Nishan Sudheera Kalupahana, Thilak Jayalath, Shu Wang, Naima Moustaid-Moussa
Pages 49-60
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- Nishan Sudheera Kalupahana, Shu Wang, Shaikh M. Rahman, Naima Moustaid-Moussa
Pages 61-71
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- Tabitha C. Ting, Makoto Miyazaki
Pages 73-84
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- Pawel Dobrzyn, Agnieszka Dobrzyn
Pages 85-101
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- Joseph Stevens, Matthew W. Hulver
Pages 103-118
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- Jennifer L. Cantley, Lucas M. O’Neill, James M. Ntambi, Michael P. Czech
Pages 119-130
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- Laura M. Bond, James M. Ntambi
Pages 131-140
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- L. Bernard, C. Leroux, Y. Chilliard
Pages 161-193
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- Silvia Graciela Altabe, MarÃa Cecilia Mansilla, Diego de Mendoza
Pages 209-231
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Back Matter
Pages 233-239
About this book
Obesity and diabetes develop as a complex result of genetic, metabolic and environmental factors and are characterized by increased lipogenesis and lipid accumulation in many tissues. Stearoyl-CoA desaturase (SCD) genes are a critical regulator of lipogenesis and catalyzes the synthesis of monounsaturated fatty acids (MUFA), mainly oleoyl- (18:1n9) and palmitoleoyl-CoA (16:1n7). These MUFAs are the major fatty acid substrates for the synthesis of triglycerides, cholesterol esters, wax esters and membrane phospholipids. There are 4 SCD isoforms (SCD1-4) in mice and two (hSCD1 and hSCD5) expressed in humans.  At first glance, stearoyl-CoA desaturase enzyme would be considered a housekeeping enzyme because it synthesizes oleate a well-known fatty acid that is abundant in many dietary sources. However numerous studies have shown that SCD is a very highly regulated enzyme that features in so many physiological processes ranging from fat differentiation, carbohydrate and fat metabolism, inflammation and cancer. The editor’s studies using stearoyl-CoA desaturase knockout (SCD1-/-) mice and studies of other investigators using pharmacological approaches to reduce SCD1 expression in mouse tissues have all established that the expression of SCD1 gene isoform represents a key step in partitioning of lipids between storage and oxidation. High SCD expression favors fat storage leading to obesity while reduced SCD expression favors fat burning and leanness. Although these studies clearly illustrated that SCD1 expression is involved in the development of obesity and insulin resistance, questions remain in the elucidation of the mechanisms involved and role of SCD1.  This book includes chapters by leading researchers on SCD Genes in the brain, heart, muscle, liver metabolism, Colitis, and more. ​
Editors and Affiliations
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Departments of Biochemistry and Nutritional Sciences, University of Wisconsin-Madison, Madison, USA
James M. Ntambi, Ph.D.
