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Biomedical Sciences - Human Genetics | Genetic Damage in Human Spermatozoa

Genetic Damage in Human Spermatozoa

Baldi, Elisabetta, Muratori, Monica (Eds.)

2013, XIII, 195 p. 22 illus., 17 illus. in color.

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  • This book will cover all possible DNA damage in sperm
  • The book will also discuss its relation to fertility and transgenerational heritable effects
  • Chapter structure will include mechanisms of damage, consequences in reproduction, possibility to eliminate damage, and possible transgenerational heritable effects   ​

There are several types of damage that can be found in the male gamete. Genetic damage in spermatozoa can originate during spermatogenesis, or it can originate during transit in both male and female genital tracts. Damage can also be due to ageing, environmental or iatrogenic conditions, as well as to the protocols to cryopreserve and to select spermatozoa in assisted reproduction techniques. This book provides a comprehensive resource for all possible DNA damages in sperm, the relation to fertility and infertility, and possible transgenerational heritable effects.

Content Level » Research

Keywords » epigenetic damage - genetic damage - human genetics - human spermatozoa

Related subjects » Gynecology - Human Genetics - Internal Medicine

Table of contents 

Structure of chromatin in spermatozoa.- Genomic changes in spermatozoa of aging male.- Chromosomal aberrations and aneuploidies.- The sperm epigenome: implications for the embryo.- Paternal reprogramming of genome: transgenerational effects.- Alterations in protamination.- Sperm DNA fragmentation and base oxidation.- Iatrogenic Genetic damage.- Sperm selection: effect on sperm DNA quality.- Effect of antioxidant treatments on sperm genetic damage.- Index.

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