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Angiogenesis and Anti-Angiogenesis in Hematological Malignancies

  • Book
  • © 2014

Overview

Authors:
  1. Domenico Ribatti

    1. Basic Medical Sciences, Neurosciences and Sensory Organs, University of Bari Medical School, Bari, Italy

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  • Describes the critical role Angiogenesis plays in tumor progression and metastasis
  • Information on Anti-angiogenesis, one of most promising approaches to the treatment of cancer and metastasis
  • Deals with several anti-angiogenic molecules currently used alone or in combination in the treatment of haematological malignancies
  • Includes supplementary material: sn.pub/extras

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Table of contents (6 chapters)

  1. Front Matter

    Pages i-xi
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  2. Introduction

    • Domenico Ribatti
    Pages 1-5

  3. Angiogenesis in Multiple Myeloma

    • Domenico Ribatti
    Pages 7-33

  4. Angiogenesis in Lymphomas

    • Domenico Ribatti
    Pages 35-47

  5. Angiogenesis in Leukemia

    • Domenico Ribatti
    Pages 49-55

  6. Anti-angiogenesis

    • Domenico Ribatti
    Pages 57-84

  7. Concluding Remarks

    • Domenico Ribatti
    Pages 85-87

  8. Back Matter

    Pages 89-114
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Keywords

About this book

It has been generally accepted that angiogenesis is involved in the pathogenesis of hematological malignancies, like acute and chronic leukemia, lymphoma, myelodysplastic syndromes, myeloproliferative neoplasms and multiple myeloma. The extent of angiogenesis in the bone marrow has been correlated with disease burden, prognosis and treatment outcome. Reciprocal positive and negative interactions between tumor cells and bone marrow stromal cells, namely hematopoietic stem cells, fibroblasts, osteoblasts/osteoclasts, endothelial cells, endothelial progenitor cells, T cells, macrophages and mast cells, mediated by an array of cytokines, receptors and adhesion molecules, modulate the angiogenic response in hematological tumors. More recently, it has been emphasized the pro-angiogenic role of the so called “vascular niche”, indicating a site rich in blood vessels where endothelial cells and mural cells such as pericytes and smooth muscle cells create a microenvironment that affects the behavior of several stem and progenitor cells, in hematological malignancies.

Reviews

From the reviews:

“This book will appeal mainly to researchers in the field of angiogenesis/antiangiogenesis, and students. … This is a comprehensive book on an important area of cancer research that is often overshadowed by literature on solid tumors. It will be most helpful for researchers looking for information on the subject, but it also enlightens practitioners on the mechanisms of action of some common treatments for hematological malignancies.” (Leslie Popplewell, Doody’s Book Reviews, June, 2014)

Authors and Affiliations

  • Basic Medical Sciences, Neurosciences and Sensory Organs, University of Bari Medical School, Bari, Italy

    Domenico Ribatti

Bibliographic Information

  • Book Title: Angiogenesis and Anti-Angiogenesis in Hematological Malignancies

  • Authors: Domenico Ribatti

  • DOI: https://doi.org/10.1007/978-94-017-8035-3

  • Publisher: Springer Dordrecht

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Science+Business Media Dordrecht 2014

  • Hardcover ISBN: 978-94-017-8034-6Published: 20 January 2014

  • Softcover ISBN: 978-94-024-0305-3Published: 17 September 2016

  • eBook ISBN: 978-94-017-8035-3Published: 06 January 2014

  • Edition Number: 1

  • Number of Pages: XI, 114

  • Number of Illustrations: 14 b/w illustrations, 30 illustrations in colour

  • Topics: Cancer Research, Oncology, Hematology, Life Sciences, general

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