Electric Cell-Substrate Impedance Sensing and Cancer Metastasis

1. Front Matter

   Pages i-viii

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2. Electric Cell-Substrate Impedance Sensing Concept to Commercialization

   • Ivar Giaever, Charles R. Keese

   Pages 1-19

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3. Protein Kinase C Isoforms in the Formation of Focal Adhesion Complexes: Investigated by Cell Impedance

   • Havovi Chichger, Katie L. Grinnell, Elizabeth O. Harrington

   Pages 21-39

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4. ECIS as a Tool in the Study of Metastasis Suppressor Genes: Epithelial Protein Lost In Neoplasm (EPLIN)

   • Andrew J. Sanders, Vladimir M. Saravolac, Malcolm D. Mason, Wen G. Jiang

   Pages 41-54

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5. Electrical Cell-Substrate Impedance Sensing for Measuring Cellular Transformation, Migration, Invasion, and Anticancer Compound Screening

   • Bryan Plunger, Chang Kyoung Choi, Tim E. Sparer

   Pages 55-69

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6. Epithelial-Mesenchymal Transition and the Use of ECIS

   • Jane Lane, Wen G. Jiang

   Pages 71-84

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7. Cell Growth and Cell Death Studied by Electric Cell-Substrate Impedance Sensing

   • Judith Anthea Stolwijk, Stefanie Michaelis, Joachim Wegener

   Pages 85-117

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8. Tight Junctions in Cancer Metastasis and Their Investigation Using ECIS (Electric Cell-Substrate Impedance Sensing)

   • Tracey A. Martin, Wen G. Jiang

   Pages 119-130

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9. Epithelial Wound Healing and the Effects of Cytokines Investigated by ECIS

   • Katalin Szaszi, Matthew Vandermeer, Yasaman Amoozadeh

   Pages 131-175

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10. Tumour-Endothelial and Tumour-Mesothelial Interactions Investigated by Impedance Sensing Based Cell Analyses

    • Wen G. Jiang, Lin Ye, Haiying Ren, Ann Kift-Morgan, Nicholas Topley, Malcolm D. Mason

    Pages 177-193

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11. Application of Electric Cell-Substrate Impedance Sensing in Evaluation of Traditional Medicine on the Cellular Functions of Gastric and Colorectal Cancer Cells

    • Lin Ye, Ke Ji, Jiafu Ji, Rachel Hargest, Wen G. Jiang

    Pages 195-202

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12. Electric Cell-Substrate Impedance Sensing as a Screening Tool for Wound Healing Agents

    • Cheuk Lun Liu, Jacqueline Chor Wing Tam, Andrew J. Sanders, David G. Jiang, Chun Hay Ko, Kwok Pui Fung et al.

    Pages 203-216

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13. ECIS, Cellular Adhesion and Migration in Keratinocytes

    • David C. Bosanquet, Keith G. Harding, Wen G. Jiang

    Pages 217-237

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14. Current and Future Applications of ECIS Models to Study Bone Metastasis

    • Lin Ye, Sivan M. Bokobza, Howard G. Kynaston, Wen G. Jiang

    Pages 239-253

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15. Back Matter

    Pages 255-260

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Cell based impedance sensing is becoming a new biophysical and cellular technology in cell based analyses. The technology has been used in investigation of cellular growth and death, cell adhesion and migration, cell invasion and cell-cell interactions, cell toxicity, angiogenesis, cell permeability, signal transduction and cellular behaviour under flow conditions. It is a probe free, highly sensitive, and versatile technology platform. Recent development in the technology has also allowed high throughput, automated analyses. It has been widely explored in chemistry, toxicity, cell biology, cancer biology, and other areas of chemistry, medicinal chemistry, life and medical science. Written by experts in the area of cell impedance sensing, including the Nobel Laureate Dr Ivar Giaever, this books covers the background of electric cell-substrate impedance sensing, their applications in cell based investigations, particularly in the area of cancer biology. This book is the first on thistechnology platform and will be a highly useful reference for molecular and cell biologists, cancer biologists, chemists and biochemists, clinical researchers who work in the areas of cell biology, molecular biology, toxicology, pharmaceutical industry, life science and medical research.

• Cancer
• Cell biology
• Cell signalling
• Impedance Sensing
• Metastasis

• Research Group Dept. Of Surgery College, Of Medicine, Univ.Of Wales Metastatis, Cardiff, United Kingdom

  Wen G. Jiang

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