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Structure of the book is based on anatomical areas of cancer dissemination that has clinical relevance
Any chapter is written/supervised by leading researcher in specific area of metastasis research
The book is focused on experimental approach of metastatic cancer research: any chapter contains supportive theoretical information and detailed description of relevant laboratory procedures
The book is supplemented by informative illustrations, schemes and tables
Extensive lists of references for any chapter provides with possibility of effective deep study
Metastatic dissemination remains a main cause for cancer related deaths. Investigation of the molecular mechanisms of the metastatic process presents an important area of cancer research and may provide clinical oncologists with new methods to prevent and manage cancer dissemination.
Availability of adequate experimental models is an essential requirement of the productive investigation. Over the many years of cancer research, plenty of model systems (in vitro and in vivo) were created to reproduce certain steps or to estimate certain aspects of metastatic process. Currently right selection and correct application of the experimental models as well as analytic technique may present a challenge.
This book provide with guideline information about experimental modelling and analysis of the metastatic process. The structure of the book reflects clinical aspects: pathway and area of the metastatic dissemination. Thus, first part of book is devoted to local, mainly via lymph system, spread of head and neck, breast and pancreatic cancers. Second part is about distant, via blood stream, dissemination into brain and lung (most often sites of metastatic lesion regardless the primary tumour issue). Third part includes chapter describing methods of modelling and study specific metastatic pathways: via portal vein system and through serous cavities. Any chapter is introduced by short review of clinical/biological aspects of the specific metastatic process, provides with description of relevant laboratory techniques, supplemented with representative illustrations and extended references list. Theoretic aspects of cancer dissemination and mathematic approaches to model metastatic spread of tumour are reviewed in the last chapter.
Chapters of the book are written by leading specialists in certain areas of metastatic cancer research, therefore the book presents a comprehensive guide for researchers and may be helpful for clinical oncologists.
Content Level »Professional/practitioner
Keywords »cancer - in vitro models - in vivo models - mathematic model - metastasis