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Biomedical Sciences - Cancer Research | Homeostasis - Tumor - Metastasis

Homeostasis - Tumor - Metastasis

Banfalvi, Gaspar

2014, XI, 279 p. 71 illus., 16 illus. in color.

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  • First the reader will learn about maintaining homeostasis, then about loss of health by upsetting the biological balance
  • The consequence of unbalanced cell growth helps to understand cell death and tumor formation
  • Readers will get an idea how primary tumors cells confined to restricted areas in the body can be effectively treated without  cancerous consequences
  • Old (hematogen) and new theories (lymphatic) will help the understanding of metastatic spread of tumors

Human homeostasis refers to complex interactions to regulate and maintain the internal conditions of the organism under stable condition. In spite of the progress made on cell growth and division, the circuits that coordinate these processes and maintain the homeostatic balance between cell growth and cell death have not been clarified. Deregulation of homeostatic processes results in different forms of imbalances that can turn to diseases including hepatitis, cyrrhosis and tumor formation. Abnormal growth of tissues can lead to a broad spectrum of neoplastic diseases from tissue swelling, primary tumor formation, cancer and ultimately to secondary tumors known as metastases. Tumor formation is a complex process, that develops through many steps. The discussion of balance and its loss in cell growth, primary and secondary tumor formation necessitate basic information in chemistry (carcinogenesis), biochemistry (metabolism), physics (instrumentation), cell biology (compartments), anatomy, physiology, clinical experience (screening, medical imaging, therapy). The focus of this book has been placed on: a) balance of cell growth, b) tumor formation, c) development of cancer and metastasis, e) diagnosis and treatment of cancer. The steps of the lymphatic type of metastatic tumor spread are described. Due to the interdisciplinary nature, the book gives information for a wide audience including biology, biotechnology, molecular, ecology, medical, pharmacist, chemist students. Additional information is provided for biomedical, pharma, medical and life scientists, physicians and health care professionals.

Content Level » Research

Keywords » cell growth - cellular information - local tumor - loss of homeostasis - tumor spread

Related subjects » Biomedical Sciences - Cancer Research - Cell Biology - Environmental Health & Public Health - Higher Education

Table of contents 

1. Homeostasis
Chemical basis of biological regulation
Definition of homeostasis, allostasis
Aqueous internal environment
Optimal systems
Basic properties of living systems
Metabolism and energy production of living systems
Contribution of biological membranes to homeostasis
Function of the inner environment and its regulated parameters
Cellular, tissue and organ homeostasis
Dimensions of health
Control of processes
Levels of bioregulation
Regulation of multicellular organisms
Major regulatory systems of organisms
Regulatory mechanisms: receptors, reflexes
Maintaining human homeostasis
Evolutionary aspects and types of regeneration
Panic syndromes
2. Cell cultures
Cell cultivation
Cell cultures
Establishment of cell cultures
Development of primary tumors
Growth of cell lines
Technical aspects of cell cultivation
Sterile work under the laminar flow hood
Deep freezing, storage of cells
Cell cycle synchronization and its flow cytometric validation
Stem cells
3. Loss of homeostasis
Loss of biological balance
Tissue adaptation
Pathological hypertrophies
Callus formation
Liver regeneration
4. Tumor development
Characterization of benign and malignant tumors
Primary tumor models
Classification of tumors
Tumor tests
Techniques of tumor screening
Antitumor agents
Benign tumor formation in different tissues and their treatment
General steps in tumor formation
Benign tumors of major organs
5. Metastasis
Historical view of metastasis
Spread of tumor cells from local tissue to distant organs
Animal cancer models
Role of parathymic lymph nodes in metastasis
Importance of size distribution of tumor cells in metastasis
Metastasis in different organs



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