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First the reader will learn about maintaining homeostasis, then about loss of health by upsetting the biological balance
The consequence of unbalanced cell growth helps to understand cell death and tumor formation
Readers will get an idea how primary tumors cells confined to restricted areas in the body can be effectively treated without cancerous consequences
Old (hematogen) and new theories (lymphatic) will help the understanding of metastatic spread of tumors
Human homeostasis refers to complex interactions to regulate and maintain the internal conditions of the organism under stable condition. In spite of the progress made on cell growth and division, the circuits that coordinate these processes and maintain the homeostatic balance between cell growth and cell death have not been clarified. Deregulation of homeostatic processes results in different forms of imbalances that can turn to diseases including hepatitis, cyrrhosis and tumor formation. Abnormal growth of tissues can lead to a broad spectrum of neoplastic diseases from tissue swelling, primary tumor formation, cancer and ultimately to secondary tumors known as metastases. Tumor formation is a complex process, that develops through many steps. The discussion of balance and its loss in cell growth, primary and secondary tumor formation necessitate basic information in chemistry (carcinogenesis), biochemistry (metabolism), physics (instrumentation), cell biology (compartments), anatomy, physiology, clinical experience (screening, medical imaging, therapy). The focus of this book has been placed on: a) balance of cell growth, b) tumor formation, c) development of cancer and metastasis, e) diagnosis and treatment of cancer. The steps of the lymphatic type of metastatic tumor spread are described. Due to the interdisciplinary nature, the book gives information for a wide audience including biology, biotechnology, molecular, ecology, medical, pharmacist, chemist students. Additional information is provided for biomedical, pharma, medical and life scientists, physicians and health care professionals.
Content Level »Research
Keywords »cell growth - cellular information - local tumor - loss of homeostasis - tumor spread
Preface 1. Homeostasis Chemical basis of biological regulation Definition of homeostasis, allostasis Aqueous internal environment Optimal systems Basic properties of living systems Metabolism and energy production of living systems Contribution of biological membranes to homeostasis Function of the inner environment and its regulated parameters Cellular, tissue and organ homeostasis Dimensions of health Control of processes Levels of bioregulation Regulation of multicellular organisms Major regulatory systems of organisms Regulatory mechanisms: receptors, reflexes Maintaining human homeostasis Evolutionary aspects and types of regeneration Panic syndromes References 2. Cell cultures Cell cultivation Cell cultures Establishment of cell cultures Development of primary tumors Growth of cell lines Technical aspects of cell cultivation Sterile work under the laminar flow hood Deep freezing, storage of cells Cell cycle synchronization and its flow cytometric validation Stem cells References 3. Loss of homeostasis Loss of biological balance Tissue adaptation Pathological hypertrophies Heloma Callus formation Liver regeneration References 4. Tumor development Characterization of benign and malignant tumors Primary tumor models Classification of tumors Tumor tests Carcinogens Techniques of tumor screening Antitumor agents Benign tumor formation in different tissues and their treatment General steps in tumor formation Benign tumors of major organs References 5. Metastasis Historical view of metastasis Spread of tumor cells from local tissue to distant organs Animal cancer models Role of parathymic lymph nodes in metastasis Importance of size distribution of tumor cells in metastasis Metastasis in different organs References Abbreviations