Shurin, Michael R, Umansky, Viktor, Malyguine, Anatoli (Eds.)
2013, XVI, 745 p. 51 illus., 46 illus. in color.
Springer eBooks may be purchased by end-customers only and are sold without copy protection (DRM free). Instead, all eBooks include personalized watermarks. This means you can read the Springer eBooks across numerous devices such as Laptops, eReaders, and tablets.
You can pay for Springer eBooks with Visa, Mastercard, American Express or Paypal.
After the purchase you can directly download the eBook file or read it online in our Springer eBook Reader. Furthermore your eBook will be stored in your MySpringer account. So you can always re-download your eBooks.
This is a unique and very first book summarizing current knowledge on immune cell functioning in cancer
Focus on both experimental animal results and human clinical trials
Prepared logically linked chapter in one comprehensive review of the field
Interaction between malignant cells and their surrounding tissue plays a crucial role in tumor growth, invasiveness and spreading to the distant organs. New findings provide evidence of a principal importance of the immune cells for controlling this interaction and orchestrating multiple events in the tumor microenvironment. The balance between immune cells that support tumor progression and immune cells that sustain tumor-controlling immune surveillance is tightly regulated by various factors originated from both the malignant and non-cancerous cells in the tumor microenvironment. Analysis of multidirectional immunological responses at the tumor site allows forming a new concept of The Tumor ImmunoEnvironment, which is introduced and discussed in the present book with a particular focus on the role of immune cells in controlling the tumor microenvironment at different stages of cancer development. The main goal of this publication is to provide an overview of the current knowledge on the complex and unique role of the immune system, tumor-associated inflammation and tumor-mediated immunomodulation in cancer progression in a way that allows understanding the logistics of cellular and molecular interactions in the tumor lesions. Moreover, it is discussed how these interactions evolve during cancer progression and in response to different kinds of anticancer therapy. It is anticipated that the book will attract many researchers and clinicians in the field of basic and applied tumor immunobiology and open new opportunities for collaborative programs aiming at the development of effective and feasible therapeutic approaches to cancer treatment.