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Biomedical Sciences - Cancer Research | Cancer Genomics - Molecular Classification, Prognosis and Response Prediction

Cancer Genomics

Molecular Classification, Prognosis and Response Prediction

Pfeffer, Ulrich (Ed.)

2013, VI, 588 p. 65 illus., 61 illus. in color.

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  • Comprehensive review of the field, none yet published
  • Critical reviews written by outstanding investigators with no personal interest in the applications
  • Easy to understand for clinicians and researchers who wish to obtain an overview over the rapidly evolving field

The combination of molecular biology, engineering and bioinformatics has revolutionized our understanding of cancer revealing a tight correlation of the molecular characteristics of the primary tumor in terms of gene expression, structural alterations of the genome, epigenetics and mutations with  its propensity to metastasize and to respond to therapy. It is not just one or a few genes, it is the complex alteration of the genome that determines cancer development and progression. Future management of cancer patients will therefore rely on thorough molecular analyses of each single case.

Through this book, students, researchers and oncologists will obtain a comprehensive picture of what the first  ten years of cancer genomics have revealed. Experts in the field describe, cancer by cancer, the progress made and its implications for diagnosis, prognosis and treatment of cancer. The deep impact on the clinics and the challenge for future translational research become evident. 

Content Level » Research

Keywords » cancer genomics - copy number variation - gene expression profiling - molecular classification - prognostic signatures

Related subjects » Biomedical Sciences - Cancer Research - Human Genetics - Molecular Medicine

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