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MicroRNA Cancer Regulation

Advanced Concepts, Bioinformatics and Systems Biology Tools

  • Book
  • © 2013

Overview

Editors:
  1. Ulf Schmitz

    1. Systems Biology and Bioinformatics, University of Rostock, Rostock, Germany

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  2. Olaf Wolkenhauer

    1. Dept. of Systems Biology and Bioinformat, Universität Rostock Institut of Computer Science, Rostock, Germany

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    You can also search for this editor in PubMed   Google Scholar

  3. Julio Vera

    1. Rostock, Germany

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    You can also search for this editor in PubMed   Google Scholar

  • Contributions from internationally renowned scientists from around the globe
  • No book available with a comparable approach and content
  • First hand resource for cancer related microRNA research
  • Provides an update and reference in the fast developing field of microRNA research
  • Provides numerous case studies across the disciplines in cancer research
  • Provides a reference for tools, web resources and protocols

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 774)

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Table of contents (17 chapters)

  1. Front Matter

    Pages i-xii
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  2. MicroRNAs in Human Cancer

    • Thalia A. Farazi, Jessica I. Hoell, Pavel Morozov, Thomas Tuschl
    Pages 1-20

  3. Bioinformatics, Non-coding RNAs and Its Possible Application in Personalized Medicine

    • Simona Rossi, George A. Calin
    Pages 21-37

  4. MicroRNA Target Prediction and Validation

    • William Ritchie, John E. J. Rasko, Stéphane Flamant
    Pages 39-53

  5. MicroRNA-Regulated Networks: The Perfect Storm for Classical Molecular Biology, the Ideal Scenario for Systems Biology

    • Julio Vera, Xin Lai, Ulf Schmitz, Olaf Wolkenhauer
    Pages 55-76

  6. The p53/microRNA Network in Cancer: Experimental and Bioinformatics Approaches

    • Sabine Hünten, Helge Siemens, Markus Kaller, Heiko Hermeking
    Pages 77-101

  7. MicroRNAs in Melanoma Biology

    • Manfred Kunz
    Pages 103-120

  8. MicroRNAs in the Lung

    • Alexandra Sittka, Bernd Schmeck
    Pages 121-134

  9. The E2F1-miRNA Cancer Progression Network

    • Susanne Knoll, Stephan Emmrich, Brigitte M. Pützer
    Pages 135-147

  10. Modeling microRNA-Transcription Factor Networks in Cancer

    • Baltazar D. Aguda
    Pages 149-167

  11. Coordinated Networks of microRNAs and Transcription Factors with Evolutionary Perspectives

    • Hisakazu Iwama
    Pages 169-187

  12. Mathematical Modeling of microRNA–Mediated Mechanisms of Translation Repression

    • Andrei Zinovyev, Nadya Morozova, Alexander N. Gorban, Annick Harel-Belan
    Pages 189-224

  13. Web Resources for microRNA Research

    • Ulf Schmitz, Olaf Wolkenhauer
    Pages 225-250

  14. Discovery of microRNA Regulatory Networks by Integrating Multidimensional High-Throughput Data

    • Jian-Hua Yang, Liang-Hu Qu
    Pages 251-266

  15. Discovering Functional microRNA-mRNA Regulatory Modules in Heterogeneous Data

    • Bing Liu, Lin Liu, Anna Tsykin, Gregory J. Goodall, Murray J. Cairns, Jiuyong Li
    Pages 267-290

  16. Elucidating the Role of microRNAs in Cancer Through Data Mining Techniques

    • Luciano Cascione, Alfredo Ferro, Rosalba Giugno, Alessandro Laganà, Giuseppe Pigola, Alfredo Pulvirenti et al.
    Pages 291-315

  17. Working Together: Combinatorial Regulation by microRNAs

    • Yitzhak Friedman, Ohad Balaga, Michal Linial
    Pages 317-337

  18. Erratum

    • Thalia A. Farazi, Jessica I. Hoell, Pavel Morozov, Thomas Tuschl
    Pages E1-E1

  19. Back Matter

    Pages 339-346
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Keywords

About this book

This edited reflects the current state of knowledge about the role of microRNAs in the formation and progression of solid tumours. The main focus lies on computational methods and applications, together with cutting edge experimental techniques that are used to approach all aspects of microRNA regulation in cancer. We are sure that the emergence of high-throughput quantitative techniques will make this integrative approach absolutely necessary in the near future. This book will be a resource for researchers starting out with cancer microRNA research, but is also intended for the experienced researcher who wants to incorporate concepts and tools from systems biology and bioinformatics into his work. Bioinformaticians and modellers are provided with a general perspective on microRNA biology in cancer, and the state-of-the-art in computational microRNA biology.

Editors and Affiliations

  • Systems Biology and Bioinformatics, University of Rostock, Rostock, Germany

    Ulf Schmitz

  • Dept. of Systems Biology and Bioinformat, Universität Rostock Institut of Computer Science, Rostock, Germany

    Olaf Wolkenhauer

  • Rostock, Germany

    Julio Vera

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