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Stem Cells and Cancer Stem Cells, Volume 6

Therapeutic Applications in Disease and Injury

  • Book
  • © 2012

Overview

Editors:
  1. M.A. Hayat

    1. , Kean University, Room 213, Library building, Union, USA

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  • Treatment of cancer patients
  • Methods for tissue engineering
  • Role of growth promoting factors in cancer
  • Treatment of injuries using cell therapy
  • Extensively illustrated with color figures

Part of the book series: Stem Cells and Cancer Stem Cells (STEM, volume 6)

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Table of contents (37 chapters)

  1. Front Matter

    Pages i-xxiii
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  2. Embryonic Stem Cells

    1. Front Matter

      Pages 1-1
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    2. Propagation of Human Embryonic Stem Cells: Role of TGF β

      • Prasad Pethe, Deepa Bhartiya
      Pages 3-9

    3. Self-renewal of Embryonic Stem Cells: Cell Cycle Regulation

      • Zuzana Koledova
      Pages 11-20

    4. Gene Expression and Epigenetic Signatures of Germ Cell-Derived Pluripotent Stem Cells and Embryonic Stem Cells

      • Jessica Nolte, D. V. Krishna Pantakani, Hassan Dihazi, Ulrich Zechner
      Pages 21-34

    5. Human Embryonic Stem Cell Bank: Implication of Human Leukocyte Antigens and ABO Blood Group Antigens for Cell Transplantation

      • Jeoung Eun Lee, Myung Seo Kang, Dong Ryul Lee
      Pages 35-45

    6. Differentiation of Embryonic Stem Cells into Glutamatergic Neurons (Methods)

      • Yenshou Lin
      Pages 47-55

    7. Differentiation of Embryonic Stem Cells into Endoderm-Derived Hepatocytes

      • Amranul Haque, Toshihiro Akaike
      Pages 57-69

    8. Differentiation of Embryonic Stem Cells into Cardiomyocytes: Role of Ouabain

      • Yee-Ki Lee, Kwong-Man Ng, Wing-Hon Lai, Yau-Chi Chan, Yee-Man Lau, Hung-Fat Tse et al.
      Pages 71-78

    9. Function of Myc for Generation of Induced Pluripotent Stem Cells

      • Masato Nakagawa, Shinya Yamanaka
      Pages 79-85

    10. Differentiation of Human Pluripotent Stem Cells into Retinal Cells

      • Masha Idelson, Benjamin Reubinoff
      Pages 87-99

    11. Derivation and Invasive Function of Trophoblast from Human Pluripotent Stem Cells

      • Harry Moore, Ramya Udayashankar
      Pages 101-109

  3. Mesenchymal Stem Cells

    1. Front Matter

      Pages 111-111
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    2. Differences Between Germ-Line Stem Cells and Multipotent Adult Germ-Line Stem Cells for MicroRNAs

      • Mukesh Kumar Gupta, Hoon Taek Lee
      Pages 113-129

    3. Molecular and Signaling Pathways That Modulate Mesenchymal Stem Cell Self-renewal

      • Sarika Saraswati, Dikshya Bastakoty, Pampee P. Young
      Pages 131-141

    4. The Biology and Regenerative Potential of Stem Cells and Their Mesenchymal Progeny

      • Markus Neubauer, Heike Wegmeyer, Ralf Huss
      Pages 143-160

    5. Mesenchymal Stem Cells: Clinical Applications (An Overview)

      • Aaron Liew, Timothy O’Brien
      Pages 161-175

    6. Mesenchymal Stem Cells for the Treatment of Cancer

      • Manuel Ramírez, Javier García Castro
      Pages 177-183

    7. Treatment of Neurodegenerative Pathologies Using Undifferentiated Mesenchymal Stem Cells

      • Arianna Scuteri
      Pages 185-195

    8. Utility of Mesenchymal Stem Cell Therapy in Type 1 Diabetes

      • Robert F. Moore, Marwan Mounayar, Reza Abdi
      Pages 197-203
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Keywords

About this book

The difference among pluripotent stem cells, multipotent stem cells, and unipotent stem cells is pointed out. Vast therapeutic applications of the following specific stem cells in disease and tissue injury are discussed: human embryonic stem cells, human mesenchymal stem cells, germ cell-derived pluripotent stem cells, induced pluripotent stem cells, human umbilical cord blood-derived stem cells, breast tumor stem cells,and hematopoietic stem cells. Because of the potential of human embryonic stem cells to produce unlimited quantities of any human cell type, considerable focus is placed on their therapeutic potential. Because of their pluripotency, these cells have been used in various applications such as tissue engineering, regenerative medicine, pharmacological and toxicological studies, and fundamental studies of cell differentiation. The formation of embryoid bodies, which are three-dimensional aggregates of embryonic stem cells, is explained as this is the first step in cell differentiation. Such embryoid body culture has been widely used as a trigger for the in vitro differentiation of embryonic stem cells. The basic capacity of self-renewal of human embryogenic stem cells is explained. The role of TGF-beta in the propagation of human embryonic stem cells is discussed. The differentiation of human embryonic stem cells into neurons, hepatocytes, cardiomyocytes, and retinal cells is fully explained. Donor policies for hematopoietic stem cells are also explained.

Editors and Affiliations

  • , Kean University, Room 213, Library building, Union, USA

    M.A. Hayat

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