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Table of contents (12 chapters)
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Front Matter
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Back Matter
Keywords
About this book
Death receptors play a central role in directing apoptosis in mammalian cells. This process of active cell death is important for a number of biological processes, e.g. for the regulation of the immune system. Death receptors are cell surface receptors that transmit apoptotic signals initiated by corresponding death ligands. Many complex signaling pathways are activated and apoptosis is the final result of a complex biochemical cascade of events.
Besides their role in the induction of cell death, evidence now exists that death receptors are able to activate several non-apoptotic signaling pathways which, depending on cellular context, may lead to apoptosis resistance, secretion of pro-inflammatory proteins, proliferation and invasive growth of cancer cells.
This book looks at the molecular basis of death receptor signaling and the role of death receptors in cancer development.
Editors and Affiliations
Bibliographic Information
Book Title: Death Receptors and Cognate Ligands in Cancer
Editors: Holger Kalthoff
Series Title: Results and Problems in Cell Differentiation
DOI: https://doi.org/10.1007/978-3-642-03045-1
Publisher: Springer Berlin, Heidelberg
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer-Verlag Berlin Heidelberg 2009
Hardcover ISBN: 978-3-642-03044-4Published: 06 October 2009
Softcover ISBN: 978-3-642-26076-6Published: 14 March 2012
eBook ISBN: 978-3-642-03045-1Published: 12 March 2010
Series ISSN: 0080-1844
Series E-ISSN: 1861-0412
Edition Number: 1
Number of Pages: XIV, 280
Number of Illustrations: 11 b/w illustrations, 9 illustrations in colour
Topics: Cancer Research, Cell Biology, Molecular Medicine, Biochemistry, general, Oncology