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Next Generation Sequencing in Cancer Research, Volume 2

From Basepairs to Bedsides

  • Book
  • © 2015

Overview

Editors:
  1. Wei Wu

    1. Department of Pathology and Laboratory, Medicine, Southern Alberta Cancer Research Institute, University of Calgary, Calgary, Canada

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  2. Hani Choudhry

    1. Faculty of Science, Biochemistry Department, Center of Innovation in Personalized Medicine, King Fahd Center for Medical Research, King Abdulaziz University, Jeddah, Saudi Arabia

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    You can also search for this editor in PubMed   Google Scholar

  • In-depth coverage of single cell sequencing for cancer

  • Gives bioinformatic tools for cancer genome studies

  • Explores the latest high-throughput sequencing technologies

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Table of contents (26 chapters)

  1. Front Matter

    Pages i-xviii
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  2. Single-Cell Next-Generation Sequencing and Its Applications in Cancer Biology

    • Biaoru Li, Xiaomeng Zhang, Jie Zheng
    Pages 1-18

  3. Utility of Next-Generation Sequencing in Cancer Drug Development and Clinical Trials

    • François Thomas, Ahmad Awada
    Pages 19-37

  4. Next-Generation Sequencing in the Era of Cancer-Targeted Therapies: Towards the Personalised Medicine

    • Ashwag Albukhari, Fawzi F. Bokhari, Hani Choudhry
    Pages 39-55

  5. Mutational Similarities Across Cancers: Implications for Research, Diagnostics, and Personalized Therapy Design

    • Frederick Klauschen, Albrecht Stenzinger, Daniel Heim
    Pages 57-65

  6. Standardized Decision Support in NGS Reports of Somatic Cancer Variants

    • Rodrigo Dienstmann
    Pages 67-80

  7. Clinical Considerations in the Conduct of Cancer Next-Generation Sequencing Testing and Genetic Counseling

    • Heather Fecteau, Tuya Pal
    Pages 81-101

  8. Next-Generation Sequencing for Cancer Biomarker Discovery

    • Aarti N. Desai, Abhay Jere
    Pages 103-125

  9. Validation and Implementation of Next-Generation Sequencing Technologies in a Clinical Molecular Diagnostic Laboratory

    • Rajesh R. Singh, Rajyalakshmi Luthra
    Pages 127-135

  10. Next-Generation Sequencing Technologies and Formalin-Fixed Paraffin-Embedded Tissue: Application to Clinical Cancer Research

    • Nadine Norton
    Pages 137-154

  11. Applications of NGS to Screen FFPE Tumours for Detecting Fusion Transcripts

    • Kunbin Qu, Joffre Baker, Yan Ma
    Pages 155-177

  12. Clinical Applications of Next-Generation Sequencing of Formalin-Fixed Paraffin-Embedded Tumors

    • Cheryl L. Thompson, Vinay Varadan
    Pages 179-192

  13. ChIP-BS-Sequencing in Cancer Epigenomics

    • Karthikraj Natarajan, Fei Gao
    Pages 193-210

  14. Integrative Analysis Identifies Transcription Factor–DNA Methylation Relationships and Introduces New Avenues for Translating Cancer Epigenetics into the Clinic

    • Matthew H. Ung, Shaoke Lou, Frederick S. Varn, Chao Cheng
    Pages 211-228

  15. Differential Methylation Analysis with Next-Generation Sequencing

    • Hongyan Xu
    Pages 229-238

  16. Performance Comparison and Data Analysis Strategies for MicroRNA Profiling in Cancer Research

    • Erik Knutsen, Maria Perander, Tonje Fiskaa, Steinar D. Johansen
    Pages 239-265

  17. Small RNA Sequencing for Squamous Cell Carcinoma Research

    • Patricia Severino, Liliane Santana Oliveira, Alan Mitchell Durham
    Pages 267-277

  18. Exome Capture and Capturing Technologies in Cancer Research

    • Chandra Sekhar Reddy Chilamakuri, Leonardo A. Meza-Zepeda
    Pages 279-302

  19. The Landscape of DNA Virus Associations Across Human Cancers

    • Jian Chen, Lopa Mishra, Xiaoping Su
    Pages 303-315

  20. Using Next-Generation Sequencing to Reveal Patterns of Chromosomal Alterations in Oral Verrucous Lesions

    • Manar Samman, Neeraj Sethi
    Pages 317-343
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Keywords

About this book

Latest generation sequencing revolutionizes the fields of cancer research and oncology. This follow-up volume focuses more extensively on single cell sequencing of cancer and trials in drug resistance. Another exciting feature is the bioinformatics tools given, that can be used on cancer genome studies. Scientists around the world are attempting to find the root cause of cancer. A reasonable cancer treatment plan and potential cure is more optimistic now with the unfolding of the cancer genome. The collective knowledge of how to leverage next generation sequencing in cancer research is paving the way. The important information provided in this volume will move the field forward in developing novel targeted cancer therapies.

Editors and Affiliations

  • Department of Pathology and Laboratory, Medicine, Southern Alberta Cancer Research Institute, University of Calgary, Calgary, Canada

    Wei Wu

  • Faculty of Science, Biochemistry Department, Center of Innovation in Personalized Medicine, King Fahd Center for Medical Research, King Abdulaziz University, Jeddah, Saudi Arabia

    Hani Choudhry

About the editors

Wei Wu, M.D., Ph.D. is a Research Associate for the Department of Bio Science at the University of Calgary, specializing in the cancer genome and systems biology. He has edited two volumes with Springer. In addition, he's a member of various editorial board for journals including the International Journal of Biomedical Sciences, International Journal of Molecular Medicine and Advances in Sciences and the Research Journal of Biological Sciences. Hani Choudhry, D.Phil is a member of the Genomics Research Group at the Wellcome Trust Centre for Human Genetics at Oxford University. His expertise is in high throughput next generation sequencing.

Bibliographic Information

  • Book Title: Next Generation Sequencing in Cancer Research, Volume 2

  • Book Subtitle: From Basepairs to Bedsides

  • Editors: Wei Wu, Hani Choudhry

  • DOI: https://doi.org/10.1007/978-3-319-15811-2

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer International Publishing Switzerland 2015

  • Hardcover ISBN: 978-3-319-15810-5Published: 06 May 2015

  • Softcover ISBN: 978-3-319-37691-2Published: 17 October 2016

  • eBook ISBN: 978-3-319-15811-2Published: 25 April 2015

  • Edition Number: 1

  • Number of Pages: XVIII, 493

  • Number of Illustrations: 8 b/w illustrations, 70 illustrations in colour

  • Topics: Cancer Research, Human Genetics, Bioinformatics

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