Logo - springer
Slogan - springer

Biomedical Sciences - Cancer Research | MicroRNA Targeted Cancer Therapy

MicroRNA Targeted Cancer Therapy

Sarkar, Fazlul H. (Ed.)

2014, X, 351 p. 28 illus., 25 illus. in color.

Available Formats:
eBook
Information

Springer eBooks may be purchased by end-customers only and are sold without copy protection (DRM free). Instead, all eBooks include personalized watermarks. This means you can read the Springer eBooks across numerous devices such as Laptops, eReaders, and tablets.

You can pay for Springer eBooks with Visa, Mastercard, American Express or Paypal.

After the purchase you can directly download the eBook file or read it online in our Springer eBook Reader. Furthermore your eBook will be stored in your MySpringer account. So you can always re-download your eBooks.

 
$149.00

(net) price for USA

ISBN 978-3-319-05134-5

digitally watermarked, no DRM

Included Format: PDF and EPUB

download immediately after purchase


learn more about Springer eBooks

add to marked items

Hardcover
Information

Hardcover version

You can pay for Springer Books with Visa, Mastercard, American Express or Paypal.

Standard shipping is free of charge for individual customers.

 
$189.00

(net) price for USA

ISBN 978-3-319-05133-8

free shipping for individuals worldwide

usually dispatched within 3 to 5 business days


add to marked items

  • Unique book focusing on microRNA targeted therapy for a variety of solid tumors
  • First book which documents systems biology and network modeling of miRNAs for cancer therapy
  • The chapters in this book is supplemented by informative illustrations, colorful diagrams and tables
  • Extensive lists of references in every chapters represents state of our knowledge in miRNAs as novel targets for cancer therapy
  • Serves as a practical guide for scientists of all levels of study
Since the discovery of microRNAs (miRNAs) some twenty years ago by Victor Ambros, David Baulcombe and Gary Ruvkun, these three scientists worked to uncover the mystery of miRNA, the small segments of nucleotides that silence genes. While studying the development of the nematode worm, Ambros and Ruvkun discovered miRNA in animals, while Baulcombe discovered it in plants. Since their discovery, it took more than two decade to fully appreciate the value of miRNA in human health and diseases. Emerging evidence suggest that the activation of oncogenes and/or the inactivation of tumor suppressor genes contribute to the development and progression of tumors. The regulation of genes is by far controlled by many transcription factors which are often deregulated during the development and progression of cancer. In addition, emerging evidence clearly suggests that the deregulation of miRNAs or small non-coding RNAs could also regulate the expression of genes, and likewise, miRNA genes are also regulated by transcription factors. The most attractive feature of miRNAs is that one miRNA can regulate many target genes (mRNAs), and thus miRNA targeted therapy is highly promising because multiple genes could be regulated by targeting a single miRNA, which becomes very important for the killing of highly heterogeneous populations of cancer cells within a tumor mass. Therefore, miRNA targeted therapy is an attractive attribute of miRNA research, which is covered through eighteen chapters complied in this book “MicroRNA targeted Cancer therapy”, and it is hoped that the field of miRNA research will be appreciated through critical reading of these chapters on the cutting-edge research on miRNAs.

Content Level » Research

Keywords » Cancer Therapy - Drug Resistance - Solid Tumors - Targeted Therapy - microRNA

Related subjects » Cancer Research - Life Sciences - Medicine

Table of contents / Preface / Sample pages 

Popular Content within this publication 

 

Articles

Read this Book on Springerlink

Services for this book

New Book Alert

Get alerted on new Springer publications in the subject area of Cancer Research.