SCF and APC E3 Ubiquitin Ligases in Tumorigenesis

1. Front Matter

   Pages i-v

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2. Introduction

   • Pengda Liu, Hiroyuki Inuzuka, Wenyi Wei

   Pages 1-13

3. The Role of FBXW Subfamily of F-box Proteins in Tumorigenesis

   • Alan W. Lau, Yueyong Liu, Adriana E. Tron, Hiroyuki Inuzuka, Wenyi Wei

   Pages 15-45

4. The Role of FBXL Subfamily of F-box Proteins in Tumorigenesis

   • Brian J. North, Yueyong Liu, Hiroyuki Inuzuka, Wenyi Wei

   Pages 47-71

5. The Role of FBXO Subfamily of F-box Proteins in Tumorigenesis

   • Jianping Guo, Brian J. North, Adriana E. Tron, Hiroyuki Inuzuka, Wenyi Wei

   Pages 73-87

6. The Role of APC E3 Ubiquitin Ligase Complex in Tumorigenesis

   • Jinfang Zhang, Lixin Wan, Brian J. North, Hiroyuki Inuzuka, Wenyi Wei

   Pages 89-111

7. Conclusions and Research Perspectives

   • Pengda Liu, Brian J. North, Hiroyuki Inuzuka, Wenyi Wei

   Pages 113-116

8. Back Matter

   Pages 117-118

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This SpringerBrief explores the physiological roles of Skp1-Cullin1-F-box Complex (SCF) and Anaphase Promoting Complex (APC) in normal cells and in tumor formation. These two related, multi-subunit E3 ubiquitin ligase enzymes, APC and SCF are thought to be the major driving forces governing proper cell cycle progression. Defective cell cycle regulation leads to genomic instability and ultimately, cancer development. Selective degradation of key cell cycle regulators by the ubiquitin-proteasome system has been proven to be a major regulatory mechanism for ensuring ordered and coordinated cell cycle progression. The SCF and APC E3 ligases have been characterized to play pivotal roles in regulating the cell cycle progression by timely degrading various critical cell cycle regulators. This Brief reviews recent studies that have shown that deregulation of signaling pathways in which the two ubiquitin ligases are involved causes aberrant cell cycle regulation, in turn leading to tumorigenesis. The text also discusses how SCF and APC may present promising therapeutic targets to treat various cancers.

• E3 ubiquitin ligase
• F-box protein
• oncogene
• protein degradation
• ubiquitylation
• Cell Cycle Analysis
• Protein Structure

• Department of Pathology, Beth Israel Deaconess Medical Center Harvard Medical School, Boston, USA

  Hiroyuki Inuzuka, Wenyi Wei

Wenyi Wei, Ph.D, is Associate Professor of Pathology at Beth Israel Deaconess Medical Center, Harvard Medical School. Dr. Wei is an expert in the mE3 ubiquitin ligase complexes. He's on the editorial board of several journals including American Journal of Cancer Research, Molecular and Cellular Biology, Cancer Hallmarks, Cancer Research, and Journal of Biological Chemistry. He has published 47 scientific papers, which have received over 2,740 citations. Hiroyuki Inuzuka, Ph.D is Assistant Professor of Pathology at Beth Israel Deaconess Medical Center, Harvard Medical School.

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