Logo - springer
Slogan - springer

Biomedical Sciences - Cancer Research | SCF and APC E3 Ubiquitin Ligases in Tumorigenesis

SCF and APC E3 Ubiquitin Ligases in Tumorigenesis

Inuzuka, Hiroyuki, Wei, Wenyi

2014, V, 118 p. 11 illus. in color.

Available Formats:
eBook
Information

Springer eBooks may be purchased by end-customers only and are sold without copy protection (DRM free). Instead, all eBooks include personalized watermarks. This means you can read the Springer eBooks across numerous devices such as Laptops, eReaders, and tablets.

You can pay for Springer eBooks with Visa, Mastercard, American Express or Paypal.

After the purchase you can directly download the eBook file or read it online in our Springer eBook Reader. Furthermore your eBook will be stored in your MySpringer account. So you can always re-download your eBooks.

 
$39.99

(net) price for USA

ISBN 978-3-319-05026-3

digitally watermarked, no DRM

Included Format: PDF and EPUB

download immediately after purchase


learn more about Springer eBooks

add to marked items

Softcover
Information

Softcover (also known as softback) version.

You can pay for Springer Books with Visa, Mastercard, American Express or Paypal.

Standard shipping is free of charge for individual customers.

 
$54.99

(net) price for USA

ISBN 978-3-319-05025-6

free shipping for individuals worldwide

usually dispatched within 3 to 5 business days


add to marked items

  • Includes updated profiles of SCF and APC cellular functions and their characterized ubiquitin substrates
  • Introduces the emergent SCF family members in the human genome and summarizes phenotypes in which the adapter proteins of SCF and APC are manipulated to reflect the pathogenesis of human cancer
  • Discusses how SCF and APC may represent promising therapeutic targets to treat various types of cancers
This SpringerBrief explores the physiological roles of Skp1-Cullin1-F-box Complex (SCF) and Anaphase Promoting Complex (APC) in normal cells and in tumor formation. These two related, multi-subunit E3 ubiquitin ligase enzymes, APC and SCF are thought to be the major driving forces governing proper cell cycle progression. Defective cell cycle regulation leads to genomic instability and ultimately, cancer development. Selective degradation of key cell cycle regulators by the ubiquitin-proteasome system has been proven to be a major regulatory mechanism for ensuring ordered and coordinated cell cycle progression. The SCF and APC E3 ligases have been characterized to play pivotal roles in regulating the cell cycle progression by timely degrading various critical cell cycle regulators. This Brief reviews recent studies that have shown that deregulation of signaling pathways in which the two ubiquitin ligases are involved causes aberrant cell cycle regulation, in turn leading to tumorigenesis. The text also discusses how SCF and APC may present promising therapeutic targets to treat various cancers.

Content Level » Research

Keywords » E3 ubiquitin ligase - F-box protein - oncogene - protein degradation - ubiquitylation

Related subjects » Cancer Research - Cell Biology

Table of contents / Sample pages 

Popular Content within this publication 

 

Articles

Read this Book on Springerlink

Services for this book

New Book Alert

Get alerted on new Springer publications in the subject area of Cancer Research.