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MicroRNAs: Key Regulators of Oncogenesis

  • Book
  • © 2014

Overview

Editors:
  1. Sadegh Babashah

    1. Dept. of Molec. Genetics, Fac. of Biological Sciences, Tarbiat Modares University, Tehran, Iran

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  • The contents of this book was scrupulously designed and explicitly written
  • Ranging from the fundamental concepts to clinical applications, this book is composed of seventeen chapters organized in two parts
  • The first part is devoted to delving deep into the importance of miRNAs in cancer biology
  • The Second part of the book highlights the clinical implications of miRNAs in cancer
  • Includes supplementary material: sn.pub/extras

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Table of contents (17 chapters)

  1. Front Matter

    Pages i-xxvi
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  2. MicroRNAs: Biology and Implications in Cancer

    1. Front Matter

      Pages 1-1
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    2. MicroRNAs and Cancer: An Overview

      • Sadegh Babashah
      Pages 3-28

    3. Epigenetics, MicroRNAs and Human Cancer

      • Jiazeng Xia, Xiaoqiang Guo, Kaiyuan Deng
      Pages 29-57

    4. MicroRNAs, Diet and Cancer Chemoprevention

      • Shahana Majid, Sumit Arora, Rajvir Dahiya, Sharanjot Saini
      Pages 59-82

    5. MicroRNAs and Energy Metabolism in Cancer Cells

      • Linchong Sun, Xiaoping He, Yang Cao, Ping Gao, Huafeng Zhang
      Pages 83-95

    6. MicroRNAs in Solid Tumors

      • Gianpiero Di Leva, Michela Garofalo
      Pages 97-127

    7. MicroRNAs and Blood Cancers

      • Charles H. Lawrie
      Pages 129-153

    8. MicroRNAs and Oncogenic Human Viruses

      • Muriel Thirion, Teru Kanda, Yoshiki Murakami, Takahiro Ochiya, Hisashi Iizasa
      Pages 155-182

    9. MicroRNAs Linking Cancer and Inflammation: Focus on Liver Cancer

      • Angélique Gougelet, Sabine Colnot
      Pages 183-208

    10. MicroRNAs and Regulatory Pathways in Tumorigenesis

      • Jun Wei, Yong Li, Xiaoming Liu, William C. Cho
      Pages 209-231

    11. MicroRNA-Modulated Apoptotic and Autophagic Signaling Networks in Cancer

      • Bo Liu, Yu-quan Wei
      Pages 233-250

    12. MicroRNAs in Cancer Drug Resistance and Drug Sensitivity

      • Hugo Seca, Raquel T. Lima, M. Helena Vasconcelos
      Pages 251-293

    13. The Biological Roles of MicroRNAs in Cancer Stem Cells

      • Bin Bao, Asfar S. Azmi, Aamir Ahmad, Yiwei Li, Sanjeev Banerjee, Dejuan Kong et al.
      Pages 295-320

  3. MicroRNAs and Their Clinical Implications

    1. Front Matter

      Pages 321-321
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    2. MicroRNAs and Clinical Implications in Cancer

      • Jürgen Wittmann
      Pages 323-353

    3. MicroRNA Expression Profiling and Its Clinical Impact in Breast Cancer

      • Manuela Ferracin, Laura Lupini
      Pages 355-367

    4. MicroRNAs and Their Clinical Impact on Resistance to Anticancer Treatment

      • Kirsten Lindner, Joerg Haier, Richard Hummel
      Pages 369-386

    5. Nanocarriers and MicroRNA-Based Scenarios for Cancer Therapy

      • Babak Bakhshinejad, Mohammad Amin Javidi, Sahar Babashah, Sadegh Babashah
      Pages 387-411

    6. Challenges and Strategies for Pulmonary Delivery of MicroRNA-Based Therapeutics

      • Yu Fujita, Kazuyoshi Kuwano, Takahiro Ochiya
      Pages 413-428
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Keywords

About this book

Aberrant expression and function of microRNAs (miRNAs) in cancer have added a new layer of complexity to the understanding of development and progression of the disease state. It has been demonstrated that miRNAs have a crucial function in oncogenesis by regulating cell proliferation and apoptosis as oncogenes or tumor suppressors. The expression signatures of miRNAs provide exciting opportunities in the diagnosis, prognosis and therapy of cancer. Since miRNAs can function as either oncogenes or tumor suppressor genes in oncogenesis, the potential of using these small RNAs as therapeutic targets opens up new opportunities for cancer therapy by either inhibiting or augmenting their activity.

Editors and Affiliations

  • Dept. of Molec. Genetics, Fac. of Biological Sciences, Tarbiat Modares University, Tehran, Iran

    Sadegh Babashah

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