Overview
- The first volume to compile studies on tumor cell sensitization
- Useful for students, scientists, clinicians and pharmaceutical companies
- Includes supplementary material: sn.pub/extras
Part of the book series: Cancer Drug Discovery and Development (CDD&D)
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Table of contents(22 chapters)
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Sensitization via Membrane-Bound Receptors
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Sensitization via Inhibition of Cell Survival Pathways (Excluding Apoptotic Signaling Pathways)
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Sensitization via Transcription Factors
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Sensitization via Targeting Apoptotic Pathways
About this book
Cancer chemotherapy can be traced back to the 1940’s and since then the world has witnessed the discovery and the important application of several new drugs. The successes of combination chemotherapy suggested that all cancers can be treated provided that the correct combination of drugs at the correct doses and correct intervals are established. However, with time, tumor cells develop mechanisms of resistance to apoptosis and no longer respond to the majority of cytotoxic therapies. Sensitization of Cancer Cells for Chemo/Immuno/Radio-therapy, edited by Benjamin Bonavida, reviews novel approaches developed to reverse tumor cell resistance to chemo/immuno/radio-therapy and the use of various sensitizing agents in combination with various cytotoxics. Such sensitizing agents target gene products that regulate resistance and therefore identify novel targets for drug development. This book also introduces several of the current approaches that have been developed by established investigators in the field that are aimed at overcoming resistance. This book is the first that compiles studies on tumor cell sensitization and is useful for students, scientists, clinicians and pharmaceutical companies.
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Editors and Affiliations
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University of California at Los Angeles, Los Angeles, USA
Benjamin Bonavida
Bibliographic Information
Book Title: Sensitization of Cancer Cells for Chemo/Immuno/Radio-therapy
Editors: Benjamin Bonavida
Series Title: Cancer Drug Discovery and Development
DOI: https://doi.org/10.1007/978-1-59745-474-2
Publisher: Humana Totowa, NJ
eBook Packages: Medicine, Medicine (R0)
Copyright Information: Humana Press 2008
Hardcover ISBN: 978-1-934115-29-9
Softcover ISBN: 978-1-61737-928-4
eBook ISBN: 978-1-59745-474-2
Series ISSN: 2196-9906
Series E-ISSN: 2196-9914
Edition Number: 1
Number of Pages: XXII, 420
Topics: Cancer Research, Oncology, Pharmacology/Toxicology, Immunology