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Biomedical Sciences - Cancer Research | Chemical Carcinogenesis

Chemical Carcinogenesis

Penning, Trevor M. (Ed.)

2011, XVI, 440 p. With 2 16 page color inserts.

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  • Focuses on chemical carcinogenesis, exposure to major classes of human carcinogens and their mode-of-action, the balance between metabolic activation to form biological reactive intermediates and their detoxification, and environmental agents that can promote tumor formation
  • Appeals to graduate students, post-doctoral fellows and faculty interested in this aspect of cancer causation and research
This monograph provides a contemporary account of advances in chemical carcinogenesis. It promotes the view that it is alteration of the DNA by endogenous and exogenous carcinogens that ultimately leads to sporadic mutations which are a root cause of many human cancers. It deals with the metabolic activation of common classes of chemical carcinogens (tobacco carcinogens, heterocyclic amines, polycyclic aromatic hydrocarbons) and their detoxication. It describes the DNA-adducts that ensue and their repair mechanisms. It covers advances in structural-biology that provide a glimpse of both the DNA-repair process and the by-pass of DNA-lesions and how this informs the mutational code.  It also deals with the concepts of chemoprevention and biomarkers for biomonitoring human exposure. Many contemporary texts on the biology of cancer now focus almost exclusively on the molecular and cell biology of the disease and do not cover the initiating (DNA damaging events) of chemical carcinogenesis in depth. It is with this perceived gap-in knowledge that world experts in their particular fields have contributed to this monograph. This monograph will be an important reference re-source for students in training, postdoctoral scientists, and senior scientists knowledgeable in the field.

Content Level » Research

Keywords » Cancer - Cancer Research - Carcinogenesis - Chemical

Related subjects » Cancer Research - Pharmacology & Toxicology

Table of contents 

1.      Historical Overview of Chemical Carcinogenesis

2.      Multistage Carcinogenesis

3.      Tobacco Smoke Carcinogens and Lung Cancer

4.      Mechanisms of Estrogen Carcinogenesis: Modulation by Botanical Natural Products

5.      Heterocyclic Amines: Potential Human Carcinogens

6.      Aflatoxins and Hepatocellular Carcinoma

7.      Metabolic Activation of Chemical Carcinogens

8.      Detoxication of  Chemical Carcinogens and Chemoprevention

9.      Covalent Polycyclic Aromatic Hydrocarbon-DNA Adducts, Carcinogenicity, Structure and Function

10.  Oxidation and Deamination of DNA by Endogenous Sources

11.  Lipid Peroxide-DNA Adducts

12.  Chemical Carcinogenesis and  Epigenetics

13.  Nucletoide Excision Repair From Bacteria to Humans: Structure-Function Studies

14.  Base Excision Repair: Role of DNA Polymerase b in Late Stage Base Excision Repair

15.  O6-Alkylguanine-DNA alkyltransferase

16.  By-Pass DNA Polymerases

17.  Mutagenesis: The Outcome of Faulty Replication of DNA

18.  p53 and Ras-Mutation

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