Overview
- Provides a more complete understanding of miRNAs function
- Explore how miRNAs regulate normal development, diseases including cancers and stem cells fate
- Presents the great potential of miRNAs in CSCs and potential therapeutic advances for cancer
- Includes supplementary material: sn.pub/extras
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Table of contents (19 chapters)
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Front Matter
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The Functions and Mechanisms of MicroRNAs
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Front Matter
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MicroRNAs in Stem Cells and Progression of Cancer
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Front Matter
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Role of MicroRNA and Potential Cancer Therapeutics
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Front Matter
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Keywords
About this book
miRNAs are a class of endogenous, small non-protein coding RNA molecules (~ 22 nucleotides) which are novel post-transcriptional regulators of gene expression. Since we have hundreds of miRNAs, the major challenge is now to understand their specific biological function. In fact the experimental evidence suggests that signaling pathways could be ideal candidates for miRNA-mediated regulation. Several studies suggest that miRNAs affect the responsiveness of cells to signaling molecules such as WNT, Notch, TGF-β and EGFR. Altered expression of particular miRNAs has been implicated in the onset and development of cancer and could be used as potential biomarkers for the disease.
Recently, many studies have found miRNAs have crucial regulatory roles in Cancer stem cells (CSCs) a kind of tumor initiating cells (TICs) and dormancy. Findings also suggest that DNA methylation may be important in regulating the expression of many miRNAs in several cancer initiating cells. Several miRNAs are known to either upregulated or downregulated in CSCs when compared to non-cancerous cells from the same tissues. CSCs are a small subpopulation of cells identified in a variety of tumors and involve in self-renewal, differentiation, chemoresistance and tumorigenesis. The volume will give a comprehensive account of important advancements in the area of miRNAs and cancer.
Editors and Affiliations
About the editors
Dr. Shree Ram Singh is a Staff Scientist for the Mouse Cancer Genetics Program at the National Cancer Institute.Â
Dr. Pranela Rameshwar is a Professor of the Department of Medicine at UMDNJ-New Jersey Medical School. See attached CV for additional details.
Bibliographic Information
Book Title: MicroRNA in Development and in the Progression of Cancer
Editors: Shree Ram Singh, Pranela Rameshwar
DOI: https://doi.org/10.1007/978-1-4899-8065-6
Publisher: Springer New York, NY
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer Science+Business Media New York 2014
Hardcover ISBN: 978-1-4899-8064-9
Softcover ISBN: 978-1-4939-4491-0
eBook ISBN: 978-1-4899-8065-6
Edition Number: 1
Number of Pages: XIII, 407
Number of Illustrations: 9 b/w illustrations, 38 illustrations in colour
Topics: Cancer Research, Gene Expression, Medical Microbiology, Biomedicine general