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Biomedical Sciences - Cancer Research | Tumor-Induced Immune Suppression - Mechanisms and Therapeutic Reversal

Tumor-Induced Immune Suppression

Mechanisms and Therapeutic Reversal

Gabrilovich, Dmitry I., Hurwitz, Arthur A. (Eds.)

2nd ed. 2014, XIV, 464 p. 38 illus., 34 illus. in color.

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  • Features extensive updates to the original edition and several new chapters
  • Presents a comprehensive overview of different mechanisms of immune dysfunction
  • Discusses a number of new mechanisms that have never been discussed in a monograph report including: T-cell inhibitory molecules and regulatory tolergenic DCs

Tumor-Induced Immune Suppression - Prospects and Progress in Mechanisms and Therapeutic Reversal presents a comprehensive overview of large number of different mechanisms of immune dysfunction in cancer  and therapeutic approaches to their correction. This includes the number of novel mechanisms that has never before been discussed in previous monographs.

The last decades were characterized by substantial progress in the understanding of the role of the immune system in tumor progression. Researchers have learned how to manipulate the immune system to generate tumor specific immune response, which raises high expectations for immunotherapy  to provide breakthroughs in cancer treatment.  It is increasingly clear that tumor-induced abnormalities in the immune system not only hampers natural tumor immune surveillance,  but also limits the effect of cancer immunotherapy. Therefore, it is critically important to understand the mechanisms of tumor-induced immune  suppression to make any progress in the field and this monograph provides these important insights.

Content Level » Research

Keywords » immune suppression - mechanisms - therapeutic reversal - tumor

Related subjects » Cancer Research - Cell Biology - Evolutionary & Developmental Biology - Human Genetics - Immunology - Medical Microbiology

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