Advances in Nutrition and Cancer 2

1. Front Matter

   Pages i-xi

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2. Epidemiological Studies: Risk Factors and Diets

   1. Diet and Cancer

      • Peter Greenwald

      Pages 1-19

   2. EPIC-Italy

      • Domenico Palli, Vittorio Krogh, Antonio Russo, Franco Berrino, Salvatore Panico, Rosario Tumino et al.

      Pages 21-28

   3. Nutritional Factors in Human Cancers

      • Edward Giovannucci

      Pages 29-42

   4. Alcohol and Cancer

      • Silvia Franceschi

      Pages 43-49

   5. Energy Sources and Risk of Cancer of the Breast and Colon-Rectum in Italy

      • Adriano Favero, Maria Parpinel, Maurizio Montella

      Pages 51-55

   6. Organochlorines and Breast Cancer

      • Rossano Dello Iacovo, Egidio Celentano, Anna Maria Strollo, Giacomo Iazzetta, Immacolata Capasso, Giacomo Randazzo

      Pages 57-66

   7. Olive Oil Consumption and Cancer Mortality in Italy

      • Amleto D’Amicis, Sara Farchi

      Pages 67-71

3. Cell Growth and Differentiation: Molecular Bases of Nutrient Effects

   1. Cell Division Cycle Alterations and Human Tumors

      • Fulvio Della Ragione, Adriana Borriello, Valentina Della Pietra, Valeria Cucciolla, Adriana Oliva, Alfonso Barbarisi et al.

      Pages 73-88

   2. Regulation of p53 Function in Normal and Malignant Cells

      • Vincenzo Tortora, Paola Bontempo, Mariantonietta Verdicchio, Ignazio Armetta, Ciro Abbondanza, Ettore Maria Schiavone et al.

      Pages 89-100

   3. The Role of Micronutrients in DNA Synthesis and Maintenance

      • Robert A. Jacob

      Pages 101-113

   4. Biological Effects of Hydroxytyrosol, a Polyphenol from Olive Oil Endowed with Antioxidant Activity

      • Caterina Manna, Fulvio Della Ragione, Valeria Cucciolla, Adriana Borriello, Stefania D’Angelo, Patrizia Galletti et al.

      Pages 115-130

   5. Protective Effects of Butyric Acid in Colon Cancer

      • Gian Luigi Russo, Valentina Della Pietra, Ciro Mercurio, Rosanna Palumbo, Giuseppe Iacomino, Maria Russo et al.

      Pages 131-147

   6. Short-Chain Fatty Acid in the Human Colon

      • Giuseppe D’Argenio, Gabriele Mazzacca

      Pages 149-158

   7. Brassica Vegetables and Cancer Prevention

      • Geert van Poppel, Dorette T. H. Verhoeven, Hans Verhagen, R. Alexandra Goldbohm

      Pages 159-168

   8. Stilbenes and Bibenzyls with Potential Anticancer or Chemopreventive Activity

      • Fulvia Orsini, Luisella Verotta

      Pages 169-186

   9. Post-Translational Modifications of Eukaryotic Initiation Factor-5A (eIF-5a) as a New Target for Anti-Cancer Therapy

      • Michele Caraglia, Pierosandro Tagliaferri, Alfredo Budillon, Alberto Abbruzzese

      Pages 187-198

4. Molecular Epidemiology: An Innovative Trend in Cancer Prevention

   1. Diet, Fibers, and Colon Cancer

      • Jean Faivre, Claude Bonithon-Kopp

      Pages 199-206

   2. Phytochemicals as Modulators of Cancer Risk

      • H. Leon Bradlow, Nitin T. Telang, Daniel W. Sepkovic, Michael P. Osborne

      Pages 207-221

   3. Low Dose Exposure to Carcinogens and Metabolic Gene Polymorphisms

      • Emanuela Taioli, Seymour Garte

      Pages 223-230

This volume includes contributions presented at the Second International Sym­ posium on Nutrition and Cancer, held in Naples, Italy, in October 1998 at the National Tumor Institute "Fondazione Pascale." During the Conference, experts from different disciplines discussed pivotal and timely subjects on the interactions between human nutrition and the development of malignancies. Comparing the themes of this Meeting with those discussed at the First Sympo­ sium in 1992, the major scientific advancements certainly derive from the extensive use of molecular approaches to perform research in nutrition. Moreover, the fundamental observation of R. Doll and R. Peto (1981), which suggested that at least 35% of all cancers (with large differences among different tumors) might be prevented by dietary regimens, has been definitively confirmed by epidemiological studies. On the other hand, the relationships between diet and cancer are quite intricate and complex; it is difficult, and at the same time not methodologically correct, to reduce them to simple terms. Metabolic and hormonal factors, contaminants and biological agents, and deficiency of specific protective nutrients are all pieces of the same puzzle.

• Colon
• DNA
• antioxidant
• cancer prevention
• cell
• mortality
• prevention
• synthesis
• translation

`...most are well referenced. As such, they may provide the non-specialist reader with an update and an entry point to the wider literature. ... the book would be a valuable addition to libaries but...'
Advances in nutrition and cancer 2 (2001)

• Institute of Biochemistry of Macromolecules, Second University of Naples, Naples, Italy

  Vincenzo Zappia, Fulvio Ragione

• Institute of Clinical Surgery, Second University of Naples, Naples, Italy

  Alfonso Barbarisi

• Institute of Food Science and Technology, National Research Council, Avellino, Italy

  Gian Luigi Russo

• National Cancer Institute, Fondazione “Giovanni Pascale”, Naples, Italy

  Rossano Dello Iacovo

Policies and ethics