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Biomedical Sciences - Cancer Research | Advances in Tumor Immunology and Immunotherapy

Advances in Tumor Immunology and Immunotherapy

Rosenblatt, J., Podack, E., Barber, G.N., Ochoa, A. (Eds.)

2014, IX, 371 p. 35 illus., 29 illus. in color.

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  • Most up-to-date volume that explores evolving paradigms in antigen presentation, dendritic cell biology, the innate response and immunosuppressive mechanisms, and emerging strategies for manipulation of the immune system for therapeutic benefit that have realized success in neuroblastoma, leukemia, melanoma, lung cancer, and allogeneic transplantation
  • Highlights early successes as well as failures to provide a snapshot of the state of clinical immunotherapy with an eye to future possibilities such as combination therapies, adoptive T-cell transfer, and the retargeting of immune cells via T-cell receptor engineering
  • Enhanced understanding of mechanisms underlying T-cell anergy such as arginine deprivation, immunosuppressive cytokines, defective innate and interferon response pathways, and NKG2D downregulation have all provided new insight into suppression of anti-tumor immunity and tumor evasion
This volume explores recent advances in understanding of fundamental immunology  and insights into  the dynamic interactions between tumors and the immune system, that  provide new opportunities  for therapeutic  intervention in cancer.  Chapter topics include evolving paradigms in the innate and adaptive response,   newly appreciated immunosuppressive mechanisms,  and  novel preclinical  strategies for manipulation of the immune system for therapeutic benefit in cancer. In addition, recent successes in the clinic, and emerging opportunities are covered. Future possibilities, such as the use of antibody engineering, fusion proteins,  and the retargeting of immune cells through T-cell receptor engineering are discussed by  leaders in the field,  focusing  on recent clinical experience, promising technologies, and challenges to clinical success.

Content Level » Research

Keywords » Antibody - Cancer - Immunology - Immunotherapy - T-cell - Tumor

Related subjects » Cancer Research - Pharmacology & Toxicology

Table of contents 


Part I Immune Activation, Suppression and Manipulation of the Immune Antitumor Response

Myeloid-Derived Suppressor Cells in Cancer.....Christos E. Kyriakopoulos, Alberto J. Montero, and Claudia Marcela Diaz-Montero

The Role of B Cells in Shaping the Antitumor Immune Response......Yu Zhang, Taylor H. Schreiber, and Joseph D. Rosenblatt

Heat-Shock Protein-Based Cancer Immunotherapy.....Taylor H. Schreiber

Activation of NK Cell Responses and Immunotherapy of Cancer......George J. Weiner

Induction of Tumor Immunity by Targeted Inhibition of Nonsense-Mediated mRNA Decay.....Eli Gilboa

Employing T Cell Homeostasis as an Antitumor Strategy.....Shawn M. Jensen, Christopher C. Paustain, and Bernard A. Fox

Adoptive Cell Therapy of Systemic Metastases Using erbB-2-Specific T Cells Redirected with a Chimeric Antibody-Based Receptor.....Dinorah Friedmann-Morvinski, Tova Waks, Assaf Marcus, and Zelig Eshhar

Part II Evolving Clinical Immunotherapeutic Strategies

Immunotherapy in Renal Cell Carcinoma.....Jennifer Cudris and Jaime R. Merchan

Adoptive T-Cell Transfer as a Clinical Antitumor Strategy for Hematologic Malignancies......Aaron P. Rapoport and Nadia Ijaz

Bifunctional Antibodies: Preclinical and Clinical Applications.....Casey W. Shuptrine and Louis M. Weiner

Clinical Development of Antibody-Fusion Proteins for Cancer Therapy.....Kory L. Alderson, Amy K. Erbe, Margaret Boyden, and Paul M. Sondel

Immunologic Outcomes of Allogeneic Stem Cell Transplantation: Graft-Versus-Host and Graft-Versus-Leukemia Responses and Implications for Future Therapy.....Lazaros J. Lekakis and Krishna V. Komanduri

The Immune System in Head and Neck Squamous Cell Carcinoma: Interactions and Therapeutic Opportunities.....Paolo Serafini and Donald T. Weed

T Cell Co-regulatory Signals and Their Role in Cancer Therapy......Eitan R. Friedman, Lynn Feun, Pasquale Benedetto, and Joseph D. Rosenblatt

Assessment of Immune Response in Biotherapy Trials and Clinical Endpoints.....Theresa L. Whiteside


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