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Biomedical Sciences - Cancer Research | Molecular Pathogenesis of Colorectal Cancer

Molecular Pathogenesis of Colorectal Cancer

Haigis, Kevin M. (Ed.)

2013, VIII, 316 p. 30 illus., 29 illus. in color.

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  • Identification and characterization of targetable oncogenic pathways in colorectal cancer
  • Discussion of the current and future prospects for targeting that pathway therapeutically
  • Emerging technologies for identifying new cancer related genes, and therefore new therapeutic targets

For more than two decades, colorectal cancer has served as the paradigm for the cooperative activity of oncogenes and tumor suppressor genes in cancer initiation and progression. The depth of molecular characterization for this disease is unparalleled, with specific mutations correlated to each histologic stage of progression from normal colon to malignant colorectal cancer. We are now entering a time when molecular classification, rather than histologic classification, of cancer subtypes is driving the development of clinical trials with emerging targeted therapies.

This book explores the past, present, and future of colorectal cancer genetics, with particular emphasis on how knowledge of the molecular pathogenesis of the disease leads to the development of novel therapeutic strategies. Individual chapters discuss general topics, such as genomic instability and inflammation, or else specific pathways, for example RAS, PI3K, and TGF-b, that play a role in colorectal cancer progression.

Content Level » Research

Related subjects » Cancer Research - Cell Biology - Molecular Medicine

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