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First book to summarize the roles, the significance, and potential therapeutic targeting of transcriptional factors from the perspective of signaling cascade
Is a comprehensive look at basic and clinical science behind the functions of representative core transcriptional factors
Chapters are written by the leaders in their fields
This book presents the most up-to-date information in the area of targeted therapeutics with a particular focus on pathway-centered approaches and transcription by leading authorities in molecular cancer research. The goal is to cover several critical principles of cancer therapeutics, ranging from regulation of cancer associated genes by coregulators, cancer cell signaling, modifiers of epigenome functionality and specific protein domains, and emerging significance of splicing. The book is directed for basic and translational scientists, clinicians, clinical investigators, fellows, residents, graduate students, and educators in the areas of molecular therapeutics and cancer medicine, and medical sciences at-large. Readers will be able to grasp the overall importance of the pathway, associated pathobiology and clinical manifestation, and possible points of intervention with a goal to solidify new cancer therapeutic targets.
Content Level »Research
Keywords »Cancer - Cancer Research - Factors - Modifiers - Transcriptional
Preface.- Steroid Receptor Coactivators (SRCs) as Integrators of Multiple Signaling Pathways in Cancer Progression.- Role of Alteration/Deficiency in Activation (ADA) Complex in the Cell Cycle, Genomic Instability and Cancer.- RUNX2 Transcriptional Regulation in Development and Disease.- Epigenetic Mechanisms of Cancer Metastasis.- Regulatory Effects of Arsenic on Cellular Signaling Pathways: Biological Effects and Therapeutic Implications.- Nuclear Factors Linking Cancer and Inflammation.- Regulation of the Jak/STATs Pathways by Histone Deacetylases.- Receptor Tyrosine Kinases in the Nucleus: Nuclear Functions and Therapeutic Implications in Cancers.- Nucleolar Signaling Determines Cell Fate – The RP-Mdm2-p53 Axis Fine-Tunes Cellular Homeostasis.- Transcriptional Regulation of Lipogenesis as a Therapeutic Target for Cancer Treatment.- Selective Inhibition of Acetyl-Lysine Effector Domains of the Bromodomain Family in Oncology.- Domain Specific Targeting of Cancer.- The Potential of Targeting Splicing for Cancer Therapy.- Exploiting Cell Cycle Pathways in Cancer Therapy: New (and Old) Targets and Potential Strategies.- Histone Demethylases in Prostate Cancer.- Therapeutic Significance of Chromatin Remodeling Complexes in Cancer.- Index.