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Nuclear Signaling Pathways and Targeting Transcription in Cancer

  • Book
  • © 2014

Overview

Editors:
  1. Rakesh Kumar

    1. Washington, USA

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  • First book to summarize the roles, the significance, and potential therapeutic targeting of transcriptional factors from the perspective of signaling cascade
  • Is a comprehensive look at basic and clinical science behind the functions of representative core transcriptional factors
  • Chapters are written by the leaders in their fields

Part of the book series: Cancer Drug Discovery and Development (CDD&D)

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Table of contents (16 chapters)

  1. Front Matter

    Pages i-xii
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  2. Gene Regulation and Cancer

    1. Front Matter

      Pages 1-1
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    2. Steroid Receptor Coactivators (SRCs) as Integrators of Multiple Signaling Pathways in Cancer Progression

      • Weiwen Long, Bert W. O’Malley
      Pages 3-32

    3. Role of Alteration/Deficiency in Activation (ADA) Complex in Cell Cycle, Genomic Instability and Cancer

      • Shakur Mohibi, Shashank Srivastava, Hamid Band, Vimla Band
      Pages 33-55

    4. RUNX2 Transcriptional Regulation in Development and Disease

      • Jessica L. Brusgard, Antonino Passaniti
      Pages 57-86

    5. Epigenetic Mechanisms of Cancer Metastasis

      • Jing Liang, Yongfeng Shang
      Pages 87-104

  3. Signaling Pathway and Cancer

    1. Front Matter

      Pages 105-105
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    2. Regulatory Effects of Arsenic on Cellular Signaling Pathways: Biological Effects and Therapeutic Implications

      • Elspeth M. Beauchamp, Ruth Serrano, Leonidas C. Platanias
      Pages 107-119

    3. Nuclear Factors Linking Cancer and Inflammation

      • Kunzang Chosdol, Mohita Bhagat, Bhawana Dikshit, Evanka Madan, Parthaprasad Chattopadhyay, Subrata Sinha
      Pages 121-154

    4. Regulation of the Jak/STATs Pathways by Histone Deacetylases

      • David M. Woods, Maritza Lienlaf-Moreno, Eduardo Sotomayor, Edward Seto, Alejandro Villagra
      Pages 155-187

    5. Receptor Tyrosine Kinases in the Nucleus: Nuclear Functions and Therapeutic Implications in Cancers

      • Longfei Huo, Jennifer L. Hsu, Mien-Chie Hung
      Pages 189-229

    6. Nucleolar Signaling Determines Cell Fate: The RP-Mdm2-p53 Axis Fine-Tunes Cellular Homeostasis

      • Yong Liu, Yanping Zhang
      Pages 231-257

    7. Transcriptional Regulation of Lipogenesis as a Therapeutic Target for Cancer Treatment

      • Chenguang Wang, Jun-Yuan Ji, Lifeng Tian, Richard G. Pestell
      Pages 259-275

  4. Protein Domains and Cancer Therapeutics

    1. Front Matter

      Pages 277-277
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    2. Selective Inhibition of Acetyl-Lysine Effector Domains of the Bromodomain Family in Oncology

      • Susanne Müller, Hannah Lingard, Stefan Knapp
      Pages 279-298

    3. Domain Specific Targeting of Cancer

      • Pratik Chandrani, Amit Dutt
      Pages 299-310

  5. Targeted Cancer Therapy

    1. Front Matter

      Pages 311-311
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    2. The Potential of Targeting Splicing for Cancer Therapy

      • Ana Rita Grosso, Maria Carmo-Fonseca
      Pages 313-336

    3. Exploiting Cell Cycle Pathways in Cancer Therapy: New (and Old) Targets and Potential Strategies

      • Angela Alexander, Khandan Keyomarsi
      Pages 337-372

    4. Histone Demethylases in Prostate Cancer

      • Ling-Yu Wang, Wenchang Guo, Kevin Kim, Mamata Pochampalli, Chiu-Lien Hung, Yoshihiro Izumiya et al.
      Pages 373-397
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Keywords

About this book

At the moment, there is no dedicated book to summarize the roles, the significance, and potential therapeutic targeting of transcriptional factors from the perspective of signaling cascade, and thus, directly impacting the functionality of transcriptional factors in cancer. In addition, this book will offer a comprehensive basic and clinical science behind the functions of representative core transcriptional factors. These chapters will serve as a treasure for all those who have an interest in the basis, progression, and targeting of human cancer. Each chapter will be intended to provide comprehensive, up-to-date information by the leaders about the physiologic and pathologic roles of TFs in specific representative organ systems of prime importance. The book will consist of chapters that will give biomedical students, under and graduate students, basic sciences and clinical cancer fellows, residents and researchers, and oncology educators will get a thorough summary of the overall subject. The readers will be able to understand the important current information and views on specific TFs and its role in cancer in areas outside their own expertise or experience. A special emphasis will be also placed on the "classic" papers as well as perspectives on future directions for the field.

Editors and Affiliations

  • Washington, USA

    Rakesh Kumar

Bibliographic Information

  • Book Title: Nuclear Signaling Pathways and Targeting Transcription in Cancer

  • Editors: Rakesh Kumar

  • Series Title: Cancer Drug Discovery and Development

  • DOI: https://doi.org/10.1007/978-1-4614-8039-6

  • Publisher: Humana New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Science+Business Media New York 2014

  • Hardcover ISBN: 978-1-4614-8038-9Published: 24 August 2013

  • Softcover ISBN: 978-1-4939-0112-8Published: 23 August 2015

  • eBook ISBN: 978-1-4614-8039-6Published: 23 August 2013

  • Series ISSN: 2196-9906

  • Series E-ISSN: 2196-9914

  • Edition Number: 1

  • Number of Pages: XII, 439

  • Topics: Cancer Research, Pharmacology/Toxicology

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