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Describes the main mechanisms that govern tumor cell resistance to apoptotic stimuli
Demonstrates the identification of existing agents or the development of new agents that can serve as sensitizing agents with other cytotoxics
Features the latest research on the results of combining targeted sensitizing agents and conventional cytotoxic therapies
Patients with various cancers are treated with conventional chemotherapeutic drugs and the majority responds well to such therapies. However, there is a subset of patients who does not respond initially and another subset who no longer responds to further treatments. Clearly, in those two subsets of patients, the cancer cells exhibit mechanisms of resistance. One of the main challenges facing us to date is to develop new therapies to treat patients with the resistant tumors. The development of new effective therapies will be dependent on delineating the biochemical, molecular, and genetic mechanisms that regulate tumor cell resistance. Such mechanisms have revealed gene products that directly regulate resistance and are targets for therapy. Of interest, several FDA-approved drugs were able to overcome drug resistance and have been successfully used clinically. They have been used as monotherapy or synergized with other therapies for the treatment of resistant tumors.
This volume constitutes a total of twelve selective reviews by pioneer scientists in the field of cancer drug resistance. Specific mechanisms in drug resistance are reviewed and novel approaches are being proposed for therapeutic interventions. This volume is of general interest to scientists, clinicians, health care providers, and students.
Part I. Mechanism of tumor cell resistance to cytotoxic apoptosis drugs: Innate versus induced
1. Molecular pathway of apoptosis
2. Molecular anti-apoptotic pathways in cancer
3. Genetic mechanisms that regulate resistance
4. Oncogenesis and tumor cell resistance
5. Molecular heterogeneity of various cancers and cancer stem cells in resistance
6. Molecular signature profiles of resistance in cancers
Part II. Dominant pathways and gene products that regulate resistance
7. Resistant targets for apoptosis
8. Autocrine and Paracrine factors
10.Tumor micro environment
Part III. Selective agents that target resistant mechanisms: Direct and indirect
11. Proteasome inhibitors
12. Chemicals: free and encapsulated in nanoparticles
13. Receptor agonists and antagonists