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EBNA1 and Epstein-Barr Virus Associated Tumours

  • Book
  • © 2013

Overview

Authors:
  1. Lori Frappier

    1. University of Toronto, Toronto, Canada

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  • Provide a comprehensive account of all EBNA1 functions and cellular effects
  • Discusses mechanistic basis of these EBNA1 functions and effects
  • Gives a balanced perspective by offering the most current evidence for and against EBNA1’s direct contribution to various cancers?

Part of the book series: SpringerBriefs in Cancer Research (BRIEFSCANCER)

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Table of contents (6 chapters)

  1. Front Matter

    Pages i-vii
    Download chapter PDF

  2. Introduction

    • Lori Frappier
    Pages 1-2

  3. Roles of EBNA1 at EBV Episomes

    • Lori Frappier
    Pages 3-18

  4. EBNA1-DNA Interactions

    • Lori Frappier
    Pages 19-25

  5. EBNA1 Contributions to EBV-Associated Tumours

    • Lori Frappier
    Pages 27-32

  6. Cellular Effects of EBNA1

    • Lori Frappier
    Pages 33-42

  7. Conclusion

    • Lori Frappier
    Pages 43-43
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Keywords

About this book

This SpringerBrief is comprehensive account of the functions and effects of the Epstein-Barr virus (EBV) EBNA1 protein that relate to EBV-associated cancers and evidence for EBNA1 contributions to these cancers.   EBNA1 was the first EBV protein detected and the most critical for EBV latent infection. EBNA1 fulfills multiple functions at EBV genomes which have been described in many (sometimes confusing) reports over the last 28 years. While these were initially thought to be the only roles of EBNA1, many reports in recent years have shown that EBNA1 also directly affects cellular processes in ways that would be expected to contribute to oncogenesis. However, the degree to which EBNA1 promotes cell survival and oncogenesis in various types of human tumours is not entirely clear and a matter of debate. This book offers a current synopsis of EBNA1 functions in EBV latency, including functions in DNA replication, mitotic segregation and transcription. Mechanisms of these EBNA1 functions is also discussed as well as implications for tumourigenesis. In addition, the cellular effects of EBNA1 will be reviewed, including how EBNA1 manipulates specific cellular proteins and relationships to EBV-associated lymphomas and carcinomas.

Authors and Affiliations

  • University of Toronto, Toronto, Canada

    Lori Frappier

About the author

Lori Dawn Frappier, Ph.D., is a Professor in the Department of Molecular Genetics at the University of Toronto and a Canada Research Chair in Molecular Virology. She specializes in researching mechanisms by which viruses persist and induce cancer in human cells. According to Scopus, Dr. Frappier has an H-index of 25; she has published over 80 papers and has been cited over 2700 times. Please see attached short CV for additional details.

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