Autophagy and Cancer

1. Front Matter

   Pages i-xi

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2. Historical Overview of Autophagy

   • William A. Dunn Jr., Laura A. Schroder, John P. Aris

   Pages 1-24

3. The Core Molecular Machinery of Autophagosome Formation

   • Meiyan Jin, Daniel J. Klionsky

   Pages 25-45

4. The Origin of Autophagosomes: The Beginning of an End

   • Susana Abreu, Jana Sanchez-Wandelmer, Fulvio Reggiori

   Pages 47-61

5. Signal Transduction Regulation of Autophagy

   • Pui-Mun Wong, Xuejun Jiang

   Pages 63-93

6. Role of Autophagy in Tumorigenesis

   • Hanlin Tao, Robert Taylor Jr., Xiangang Zeng, Shengkan Jin

   Pages 95-112

7. Selective Autophagy and Cancer

   • Yoshinobu Ichimura, Masaaki Komatsu

   Pages 113-125

8. Oncogenes and Tumor Suppressor Genes in Autophagy

   • Gregor M. Balaburski, Anna Budina, Maureen E. Murphy

   Pages 127-143

9. Autophagy and Immunity

   • Lindsey M. Silva, Jae U. Jung

   Pages 145-165

10. Autophagy and the Tumor Microenvironment

    • Daolin Tang, Michael T. Lotze

    Pages 167-189

11. Autophagy and Cancer Therapy

    • Andrew Thorburn, Michael J. Morgan

    Pages 191-204

12. The Cross Talk Between Apoptosis and Autophagy

    • Megan M. Young, Hong-Gang Wang

    Pages 205-224

13. Autophagy and Cancer Drug Discovery

    • Hua Yang, Jessica A. Williams, Yifeng Hou, Menghang Xia, Ying-Hong Shi, Jia Fan et al.

    Pages 225-254

14. Back Matter

    Pages 255-261

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With the explosion of information on autophagy in cancer, this is an opportune time to speed the efforts to translate our current knowledge about autophagy regulation into better understanding of its role in cancer. This book will cover the latest advances in this area from the basics, such as the molecular machinery for autophagy induction and regulation, up to the current areas of interest such as modulation of autophagy and drug discovery for cancer prevention and treatment. The text will include an explanation on how autophagy can function in both oncogenesis and tumor suppression and a description of its function in tumor development and tumor suppression through its roles in cell survival, cell death, cell growth as well as its influences on inflammation, immunity, DNA damage, oxidative stress, tumor microenvironment, etc. The remaining chapters will cover topics on autophagy and cancer therapy. These pages will serve as a description on how the pro-survival function of autophagy may help cancer cells resist chemotherapy and radiation treatment as well as how the pro-death functions of autophagy may enhance cell death in response to cancer therapy, and how to target autophagy for cancer prevention and therapy − what to target and how to target it. ​

• autophagosomes
• autophagy
• cancer
• signal transduction

• Penn State College of Medicine, Pharmacology, Penn State Hershey Cancer Institute, Hershey, USA

  Hong-Gang Wang

Dr. Hong-Gang Wang is the Lois High Berstler Professor, Department of Pharmacology at Penn State College of Medicine. Dr. Wang is a leading research scientist in the area of autophagy and cancer.

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