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Vesicle Trafficking in Cancer

  • Book
  • © 2013

Overview

Editors:
  1. Yosef Yarden

    1. Department of Biological Regulation, Rehovot, Israel

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    You can also search for this editor in PubMed   Google Scholar

  2. Gabi Tarcic

    1. , Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel

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    You can also search for this editor in PubMed   Google Scholar

  • Discusses the evolutionary basis of endocytic pathways

  • Examines the lipid composition of the endosomal pathway

  • Explore mathematical modeling of endocytosis

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Table of contents (17 chapters)

  1. Front Matter

    Pages i-xiv
    Download chapter PDF

  2. Clathrin-Mediated Endocytosis

    • Alexander Sorkin, Manojkumar A. Puthenveedu
    Pages 1-31

  3. Intimate and Facultative? Regulation of Clathrin-Mediated Endocytosis by the Actin Cytoskeleton

    • Tal Hirschhorn, Marcelo Ehrlich
    Pages 33-56

  4. Oncogenic Signaling from the Plasma Membrane

    • Eli Zamir, Nachiket Vartak, Philippe I. H. Bastiaens
    Pages 57-74

  5. Endocytosis in the Spatial Control of Polarised Cell Functions

    • Giorgio Scita, Andrea Disanza, Emanuela Frittoli, Andrea Palamidessi, Sara Sigismund
    Pages 75-94

  6. Aberrant Vesicular Trafficking Contributes to Altered Polarity and Metabolism in Cancer

    • Shreya Mitra, Gordon B. Mills
    Pages 95-123

  7. Endocytosis and the Regulation of Cell Signaling, Cell Adhesion, and Epithelial to Mesenchymal Transition in Cancer

    • Crislyn D’Souza-Schorey, Guangpu Li
    Pages 125-138

  8. Efficient Enhancement of Signaling Capacity: Signaling Endosomes

    • Iwona Pilecka, Marta Miaczynska
    Pages 139-157

  9. Nuclear Functions and Trafficking of Receptor Tyrosine Kinases

    • Ying-Nai Wang, Jennifer L. Hsu, Mien-Chie Hung
    Pages 159-176

  10. Efficient Enhancement of Signalling Capacity: The Ubiquitin System

    • Daniela Hoeller, Ivan Dikic
    Pages 177-190

  11. Molecular Mechanism of Ubiquitin-Dependent Traffic

    • Elena Maspero, Hans-Peter Wollscheid, Simona Polo
    Pages 191-218

  12. Cbl as a Master Regulator of Receptor Tyrosine Kinase Trafficking

    • Ke Ma, Stephen C. Kales, Marion M. Nau, Stanley Lipkowitz
    Pages 219-244

  13. Regulation of Endocytic Trafficking and Signalling by Deubiquitylating Enzymes

    • Han Liu, Sylvie Urbé, Michael J. Clague
    Pages 245-259

  14. RTKs as Models for Trafficking Regulation: c-Met/HGF Receptor-c-Met Signalling in Cancer—Location Counts

    • Carine Joffre, Rachel Barrow, Ludovic Ménard, Stéphanie Kermorgant
    Pages 261-277

  15. Regulation of Epidermal Growth Factor Receptor Signaling by Endocytosis in Normal and Malignant Cells

    • Sergio Anastasi, Stefano Alemà, Oreste Segatto
    Pages 279-302

  16. Stress-Driven Endocytosis of Tyrosine-Phosphorylated EGFR Leads to Tumorigenesis: The Critical Role of Oxidative Stress

    • Tzipora Goldkorn, Simone Filosto, Samuel Chung
    Pages 303-325

  17. Internalisation, Endosomal Trafficking and Recycling of Integrins During Cell Migration and Cancer Invasion

    • Elena Rainero, Peter V. E. van den Berghe, Jim C. Norman
    Pages 327-359

  18. Antibody-Mediated Receptor Endocytosis: Harnessing the Cellular Machinery to Combat Cancer

    • Gabi Tarcic, Yosef Yarden
    Pages 361-384

  19. Back Matter

    Pages 385-393
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Keywords

About this book

Endocytosis and vesicular trafficking determine the landscape of the cell’s exterior, namely the density of surface molecules, such as receptors for growth factors and cytokines, adhesion molecules like integrins and cadherins, and a plethora of nutrient carriers. Hence, endocytosis is involved in signal transduction, cell adhesion and migration, as well as metabolism. To exploit these fundamental processes, malignancies subtly and multiply manipulate the endocytosis and the subsequent trafficking of protein cargoes. This is achieved by simultaneously altering the cytoskeleton, vesicle budding, cargo sorting and intracellular degradation. By highlighting the underlying molecular processes and concentrating on specific examples, this book reviews the recent emergence of derailed endocytosis and vesicular trafficking as a landmark of cancer. In-depth understanding of this common feature of tumors might lead the way to drug-induced strategies, able to rectify intracellular trafficking in cancer.

Editors and Affiliations

  • Department of Biological Regulation, Rehovot, Israel

    Yosef Yarden

  • , Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel

    Gabi Tarcic

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