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Biomedical Sciences - Cancer Research | Androgen-Responsive Genes in Prostate Cancer - Regulation, Function and Clinical Applications

Androgen-Responsive Genes in Prostate Cancer

Regulation, Function and Clinical Applications

Wang, Zhou (Ed.)

2013, IX, 348 p. 43 illus., 35 illus. in color.

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  • Focuses on androgen-responsive genes and prostate cancer, whereas other books have focused on androgen action and androgen receptors
  • Covers androgen-responsive genes in relation to carcinogenesis, cell growth, angiogenesis and more
  • Explores new approaches to diagnosis, prevention and treatment through understanding the mechanisms of androgen-responsive genes at the cellular level​  

Recent studies demonstrated a key role of the androgen receptor in the development of castration-recurrent or -resistant prostate cancer (CRPC), which is deadly and in urgent need of more effective therapies.  Understanding the functions of androgen-responsive genes and their regulation and deregulation in prostate cancer progression may lead to new approaches to prevent and treat prostate cancer patients. 

This book provides an up-to-date review of the overall androgen-responsive gene expression program and the regulation, function, and clinical relevance of both protein coding and non-coding androgen-responsive genes.  Experts in the field of androgen action and prostate cancer research discussed the importance of DNA elements, chromatin structure, cellular signaling, and cell-cell interactions in the regulation of androgen-responsive genes in the context of prostate cancer progression, including the development of CRPC.  This book is intended for individuals interested in cancer endocrinology and medical and healthcare professionals involved in prostate cancer research.

Content Level » Research

Keywords » androgen action - androgen receptor coregulators - chromatin looping - miR-21 - prostate tumorigenesis

Related subjects » Cancer Research - Human Genetics

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