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Biomedical Sciences - Cancer Research | Tumor Microenvironment and Cellular Stress - Signaling, Metabolism, Imaging, and Therapeutic Targets

Tumor Microenvironment and Cellular Stress

Signaling, Metabolism, Imaging, and Therapeutic Targets

Koumenis, Constantinos, Hammond, Ester, Giaccia, Amato (Eds.)

2014, X, 290 p. 38 illus., 30 illus. in color.

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  • Explores significant advances in understanding the genetic determinants of stress responses​
  • Discusses various cellular and animal models of tumor microenvironment study
  • Features novel targets for imaging and therapeutic intervention

The collection of chapters in this proceeding volume reflects the latest research presented at the Aegean meeting on Tumor Microenvironment and Cellular Stress held in Crete in Fall of 2012. The book provides critical insight to how the tumor microenvironment affects tumor metabolism, cell stemness, cell viability, genomic instability and more. Additional topics include identifying common pathways that are potential candidates for therapeutic intervention, which will stimulate collaboration between groups that are more focused on elucidation of biochemical aspects of stress biology and groups that study the pathophysiological aspects of stress pathways or engaged in drug discovery.

Content Level » Research

Keywords » drug discovery - hypoxia - microenvironment - therapy - tumor

Related subjects » Cancer Research - Human Physiology - Immunology - Medical Microbiology

Table of contents 

Introduction.- Hypoxia and metabolism in cancer.- Hypoxia and Regulation of Cancer Cell Stemness.- Hypoxia-mediated metastasis.- Escape Mechanisms from Antiangiogenic Therapy: An Immune Cell’s Perspective.- Hypoxic VDAC1: a potential mitochondrial marker for cancer therapy.- Hypoxia directed drug strategies to target the tumor microenvironment.- Radiotherapy and the Tumor Microenvironment: Mutual Influence and Clinical Implications.- Autophagy and cell death to target cancer cells: exploiting synthetic lethality as cancer therapeutic.- Intratumoral Hypoxia as the Genesis of Genetic Instability and Clinical Prognosis in Prostate Cancer.- miR-210: Fine-Tuning the Hypoxic Response.- The role of complement in tumor growth.- Imaging angiogenesis, inflammation and metastasis in the tumor microenvironment with magnetic resonance imaging.- Index.

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