p53 in the Clinics

1. Front Matter

   Pages i-x

   PDF

2. TP53: Coordinator of the Processes That Underlie the Hallmarks of Cancer

   • Pierre Hainaut

   Pages 1-23

3. The Inheritance of p53

   • Lukasz F. Grochola, Jorge Zeron-Medina, Emmanouela Repapi, Alexander E. Finlayson, Ying Cai, Gurinder Singh Atwal et al.

   Pages 25-46

4. p53: Guardian of the Metabolome

   • Masha V. Poyurovsky, Carol Prives

   Pages 47-64

5. The p53 Family and Stem Cell Biology

   • Massimiliano Agostini, Alessandro Rufini, Edward T. W. Bampton, Francesca Bernassola, Gerry Melino, Richard A. Knight

   Pages 65-76

6. Mutant p53-Driven Tumorigenesis

   • Tamara Terzian, Guillermina Lozano

   Pages 77-93

7. Humanised Mouse Models: Targeting the Murine p53 Locus with Human Sequences

   • Monica Hollstein, Yang Xu

   Pages 95-108

8. p53 Models for Mammary Carcinogenesis

   • Wolfgang Deppert, Genrich Tolstonog

   Pages 109-126

9. TP53 Somatic Mutations: Prognostic and Predictive Value in Human Cancers

   • Magali Olivier

   Pages 127-146

10. Assessing TP53 Status in Human Tumors: Lessons from Breast Cancer

    • Anita Langerød, Magali Olivier, Anne-Lise Børresen-Dale

    Pages 147-165

11. TP53 Germline Mutations: Genetics of Li–Fraumeni Syndrome

    • Doua Bakry, David Malkin

    Pages 167-188

12. Tp53 Gene Therapy for Cancer Treatment and Prevention

    • Robert E. Sobol, Yong-Song Guan, Long-Jiang Li, Wei-Wei Zhang, Zhaohui Peng, Kerstin B. Menander et al.

    Pages 189-208

13. Upstream Targets in the p53 Pathway

    • Anna R. McCarthy, Sonia Lain

    Pages 209-229

14. p53-Reactivating Molecules as Research Tools and Anticancer Drugs

    • Vera V. Grinkevich, Andreas Warnecke, Galina Selivanova

    Pages 231-255

15. Targeting Mutant p53 for Improved Cancer Therapy

    • Jinfeng Shen, Vladimir J. N. Bykov, Klas G. Wiman

    Pages 257-273

16. p53 Immunotherapy of Cancer

    • Hakim Echchannaoui, Matthias Theobald

    Pages 275-287

17. Designing p53 Trials: A Surgical Oncologists View

    • Daniela Kandioler, Sonja Kappel, Brigitte Wolf

    Pages 289-303

18. p53 in the Clinic: A Pathologist’s View

    • Philippe Bertheau, Jean-François Fléjou, Yves Allory, Pascale Varlet, Sylvie Lantuejoul, Louis-François Plassa et al.

    Pages 305-326

19. Genetic Counseling for TP53 Germline Mutations

    • Maria Isabel Waddington Achatz, Patricia Ashton-Prolla

    Pages 327-343

20. Back Matter

    Pages 345-355

    PDF

This project follows on the success of the book "25 years of p53", published by Springer in 2006. Since this publication, there have been considerable advances on the potential application of p53 into the clinics. The goal of this book is to capture these developments and to appeal to a clinical and medical audience beyond the one which was the primary target of "25 years of p53".

• TP53
• cancer research
• chromosome 17
• protein kinase
• tumor suppressor protein
• ubiquitin ligases

• International Prevention Research Instit, Lyon, France

  Pierre Hainaut

• International Agency for Cancer Research, Lyon, France

  Magali Olivier

• Cancer Center Karolinska (CCK), Dept. Oncology and Pathology, Karolinska Institute, Stockholm, Sweden

  Klas G. Wiman

Policies and ethics