Hainaut, Pierre, Olivier, Magali, Wiman, Klas G. (Eds.)
2013, X, 358 p.
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Focuses on recent advances in translational research on p53
Explores the significance of the genetic diversity of p53
Discusses mutations as biomarkers in molecular pathology
With over 60,000 referenced publications, p53 has emerged as one of the most important factors in human cancer. Research on p53 has led to a complete overhaul of our understanding of the molecular basis of human cancer. In recent years, these major advances in knowledge are starting to impact on cancer management and therapy. This book thus captures a critical turning point in p53 research, from basic to translational research and clinical application.
p53 in the Clinics follows the success of 25 Years of p53 Research and condensates in a series of authoritative chapters the considerable progress on the applications of p53 into the clinics and the substantial advances on diseases caused by inheritance of p53 defects, on somatic p53 mutations as biomarkers in molecular pathology, on progress in gene therapy and on developments of innovative drugs and clinical trials. This volume will appeal to a wide audience of students and professionals in basic and clinical cancer research and treatment, and will highlight the exciting “next steps” in p53 research and applications.
Content Level »Research
Keywords »TP53 - cancer research - chromosome 17 - protein kinase - tumor suppressor protein - ubiquitin ligases
Foreword.- p53 activities and the hallmarks of cancer.- The inheritance of p53.- p53: Guardian of the metabolome.- The p53 family and stem cell biology.- Mutant p53-driven tumorigenesis.- Humanized p53 mouse models.- p53 models for mammary carcinogenesis.- TP53 somatic mutations: Prognostic and predictive value in human cancers.- Assessing TP53 status in human tumors - lessons from breast cancer.- TP53 germline mutations: Genetics of Li-Fraumeni Syndrome.- TP53 gene therapy.- Upstream targets in the p53 pathway.- p53-reactivating molecules as research tools and anti-cancer drugs.- Restoring mutant p53 activity.- p53-immunotherapy of cancer.- Designing p53 trials: a surgical oncologist view.- p53 in the clinic: a pathologist view.- p53 in genetic counseling.- Index.