Logo - springer
Slogan - springer

Biomedical Sciences - Cancer Research | Designs for Clinical Trials - Perspectives on Current Issues

Designs for Clinical Trials

Perspectives on Current Issues

Harrington, David (Ed.)

2012, XIV, 206 p.

Available Formats:
eBook
Information

Springer eBooks may be purchased by end-customers only and are sold without copy protection (DRM free). Instead, all eBooks include personalized watermarks. This means you can read the Springer eBooks across numerous devices such as Laptops, eReaders, and tablets.

You can pay for Springer eBooks with Visa, Mastercard, American Express or Paypal.

After the purchase you can directly download the eBook file or read it online in our Springer eBook Reader. Furthermore your eBook will be stored in your MySpringer account. So you can always re-download your eBooks.

 
$169.00

(net) price for USA

ISBN 978-1-4614-0140-7

digitally watermarked, no DRM

Included Format: PDF and EPUB

download immediately after purchase


learn more about Springer eBooks

add to marked items

Hardcover
Information

Hardcover version

You can pay for Springer Books with Visa, Mastercard, American Express or Paypal.

Standard shipping is free of charge for individual customers.

 
$219.00

(net) price for USA

ISBN 978-1-4614-0139-1

free shipping for individuals worldwide

usually dispatched within 3 to 5 business days


add to marked items

Softcover
Information

Softcover (also known as softback) version.

You can pay for Springer Books with Visa, Mastercard, American Express or Paypal.

Standard shipping is free of charge for individual customers.

 
$219.00

(net) price for USA

ISBN 978-1-4614-2953-1

free shipping for individuals worldwide

usually dispatched within 3 to 5 business days


add to marked items

  • Each chapter will be written by an expert conducting research in the topic of that chapter.
  • This book examines current issues and controversies in the design of clinical trials, including topics in adaptive and sequential designs, the design of correlative genomic studies, and the design of studies in which missing data is anticipated.
  • The chapters serve as a guidance for statisticians designing trials.

Statistical methods for clinical trials have been an area of active research in Biostatistics since the first modern clinical trials were mounted in 1946 by the British Medical Research Council in whooping cough and tuberculosis.  Often, the participants in clinical trials suffer from potentially fatal chronic diseases, and it is especially important that these experiments in medical research use designs that are efficient, can be understood by physicians, policy makers and patients, respond quickly new ideas in medicine and statistics, and, perhaps above all, show respect for the complex and important ethical issues that arise in these settings.

 

This book explores some recent thinking in designs for clinical trials, including alternative designs for phase I studies, interim monitoring for futility, adaptive designs based on accumulating outcome data, and designs of new, targeted therapies.  The book is intended for both the statistical practitioner, who may be too busy to stay abreast of the literature on statistical methods, as well as statisticians conducting research in clinical trials.

Content Level » Research

Keywords » HIV prevention trials - adaptive designs - cancer clinical trials - correlative genomic studies - randomization algorithms

Related subjects » Cancer Research - Pharmacology & Toxicology

Table of contents 

New designs for phase I dose finding studies.- Phase II/III designs for trials.- Design issues for clinical studies with genomic measurements.- Designing studies with longitudinal measurements subject to dropout.- Issues in sample size re-estimation.- Adaptive designs.- The design of non-inferiority trials.- Issues in the design of HIV prevention trials.- Randomization algorithms.- Sequential designs for phase III studies.- Case studies of difficult designs.- Ethical issues in the design of trials.- Index.

Popular Content within this publication 

 

Articles

Read this Book on Springerlink

Services for this book

New Book Alert

Get alerted on new Springer publications in the subject area of Cancer Research.