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Biomedical Sciences - Cancer Research | Insulin Resistance and Cancer - Epidemiology, Cellular and Molecular Mechanisms and Clinical Implications

Insulin Resistance and Cancer

Epidemiology, Cellular and Molecular Mechanisms and Clinical Implications

Fantus, I. George (Ed.)

2011, XII, 300 p.

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  • In-depth detail of basic concepts of insulin and cancer and how they interact.
  • Reviews the epidemiological associations between insulin resistance and cancer.
  • Focuses primarily on breast cancer as a key and significant model for cancer research and insulin.
This book reviews the epidemiological associations between insulin resistance and cancer. This is followed by reviews of animal models which support this relationship and provide insight into potential mechanisms. Several chapters then provide detailed examination of the cellular and molecular changes characterizing the insulin resistant state, such as hyperinsulinemia, abnormal metabolism and hormone signaling, and how these interact with various tumor characteristics. For example some tumors present increased quantities of the fetal form of the insulin receptor, unique regulation of oxidative (Krebs’ cycle) metabolism (Warburg effect), as well as mutations in various relevant signaling pathways. Finally, the clinical implications of these data are integrated with considerations of insulin “sensitization” and potential metabolic interventions to prevent and treat cancer. It should be noted that while a number of cancers are associated with obesity the authors here have focused primarily on breast cancer as a key and significant model.

Content Level » Research

Keywords » Hyperinsulinemia - IGF Receptors - breast cancer - metabolic syndrome - obesity

Related subjects » Cancer Research - Pharmacology & Toxicology

Table of contents 

Insulin and the Physiology of Carbohydrate and Lipid Metabolism.

2. Insulin Signalling: Cellular and Molecular Mechanisms

3. Mechanisms of Insulin Resistance, Obesity and Metabolic Syndrome

4. Obesity and Cancer: Epidemiology

5. Insulin, Insulin Resistance and Cancer Associations

6. Animal Models of Hyperinsulinemia, Insulin Resistance and Cancer

7. Actions of Insulin as a Survival and Growth Factor: Akt/PKB, mTOR and MAPK Signaling.

8. Potential Mechanisms Linking Insulin to Cancer

9. Insulin-like Growth Factors and Cancer

10. Insulin, IGF Receptors and Cancer

11. Clinical Implications for Cancer Treatment and Prevention

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