Logo - springer
Slogan - springer

Biomedical Sciences - Cancer Research | Cell Cycle Deregulation in Cancer

Cell Cycle Deregulation in Cancer

Enders, Greg H. (Ed.)

2010, VIII, 206p. 19 illus., 11 illus. in color.

Available Formats:
eBook
Information

Springer eBooks may be purchased by end-customers only and are sold without copy protection (DRM free). Instead, all eBooks include personalized watermarks. This means you can read the Springer eBooks across numerous devices such as Laptops, eReaders, and tablets.

You can pay for Springer eBooks with Visa, Mastercard, American Express or Paypal.

After the purchase you can directly download the eBook file or read it online in our Springer eBook Reader. Furthermore your eBook will be stored in your MySpringer account. So you can always re-download your eBooks.

 
$229.00

(net) price for USA

ISBN 978-1-4419-1770-6

digitally watermarked, no DRM

Included Format: PDF and EPUB

download immediately after purchase


learn more about Springer eBooks

add to marked items

Hardcover
Information

Hardcover version

You can pay for Springer Books with Visa, Mastercard, American Express or Paypal.

Standard shipping is free of charge for individual customers.

 
$289.00

(net) price for USA

ISBN 978-1-4419-1769-0

free shipping for individuals worldwide

usually dispatched within 3 to 5 business days


add to marked items

Softcover
Information

Softcover (also known as softback) version.

You can pay for Springer Books with Visa, Mastercard, American Express or Paypal.

Standard shipping is free of charge for individual customers.

 
$289.00

(net) price for USA

ISBN 978-1-4614-2569-4

free shipping for individuals worldwide

usually dispatched within 3 to 5 business days


add to marked items

  • Includes 11 reviews by leading experts in tumorigenesis
  • Outlines major cell cycle perturbations that drive tumorigenesis
  • Explores the prospects for using such knowledge in cancer therapy

Modern studies of regulation of the cell division cycle were pioneered by Leland Hartwell, Paul Nurse, and Tim Hunt in yeast and marine invertebrates. This work identified proteins termed cyclins that fluxuate in abundance during progression through the cycle and partner with Cyclin dependent kinases (Cdks) to drive major cell cycle transitions. Much has been learned since about how these and other proteins control cell cycle progression in all eukaryotes, including man. Further research is uncovering how these controls are de-regulated in cancer, a disease of unbridled cell proliferation that is the leading cause of death in developed countries. However, there is much more to be learned, and the hard won gains are just beginning to impact cancer care. In 11 reviews by leading experts, this volume lays out the current state and directions of the field for biomedical scientists of all training levels.

The collection begins with three reviews that delineate how cells initiate the cell cycle, from growth factor stimulation to activation of key transcription programs and origins of DNA replication. The next three reviews address issues of proliferation under duress, including how derangement of mitotic checkpoints can lead to cell death or genetic instability and how recycling of intracellular molecules (autophagy) is regulated. The next three reviews address the special context of long-term proliferation—how it is regulated in stem cells, how it can erode telomeric structures on the tips of chromosomes, and how it can culminate in senescence. The last two reviews describe how cell cycle advances are beginning to touch patients, in the characterization of pre-malignant states and in cancer therapy.

Content Level » Research

Keywords » DNA - biology - cancer - cancer therapy - cell - esophagus - research - senescence - tumor - tumorigenesis

Related subjects » Cancer Research - Pharmacology & Toxicology

Table of contents / Preface / Sample pages 

Popular Content within this publication 

 

Articles

Read this Book on Springerlink

Services for this book

New Book Alert

Get alerted on new Springer publications in the subject area of Cancer Research.