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Biomedical Sciences - Cancer Research | Cancer Genome and Tumor Microenvironment

Cancer Genome and Tumor Microenvironment

Series: Cancer Genetics

Thomas-Tikhonenko, Andrei (Ed.)

2010, IX, 480p. 58 illus., 29 illus. in color.

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  • Reviews how tumor microenvironment and progression are “hard-wired” at the genetic level

Oncogenes and tumor suppressor genes had been traditionally studied in the context of cell proliferation, differentiation, senescence, and survival, four relatively cell-autonomous processes. Consequently, in the late ‘80s-mid ‘90s, neoplastic growth was described largely as a net imbalance between cell accumulation and loss, brought about through mutations in cancer genes. In the last ten years, a more holistic understanding of cancer slowly emerged, stressing the importance of interactions between neoplastic and various stromal components: extracellular matrix, basement membranes, fibroblasts, endothelial cells of blood and lymphatic vessels, tumor-infiltrating lymphocytes, etc . Nevertheless, the commonly held view is that changes in tumor microenvironment are "soft-wired", i.e. epigenetic in nature and often reversible. Yet, there exists a large body of evidence suggesting that well-known mutations in cancer genes profoundly affect tumor milieu. In fact, these cell-extrinsic changes might be one of the primary reasons such mutations are preserved in late-stage tumors. Cancer Genome and Tumor Microenvironment reviews how tumor microenvironment and progression can be "hard-wired", i.e. genetically controlled.

Content Level » Professional/practitioner

Keywords » Chromosom - angiogenesis - cell - genes - lymphocytes - lymphoma - melanoma - metastasis - senescence - tumor - tumor progression

Related subjects » Cancer Research - Oncology & Hematology

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