Editors:
- Describes the contribution of the tumor microenvironment to tumor growth and metastasis
- Gives a unique opportunity to understand the cross talk between tumor cells (the seed) and the organ microenvironment (the soil)
- Discusses therapy targeting the microenvironment rather than the tumor cells
Part of the book series: The Tumor Microenvironment (TTME, volume 2)
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Table of contents (7 chapters)
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Front Matter
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Back Matter
About this book
It is now becoming very clear that the development and progression of tumor towards the malignant (metastatic) phenotype depends tightly on the interaction between the tumor cells and the tumor microenvironment. Tumor cells respond to stimuli generated within the tumor microenvironment for their growth advantage while the tumor cell themselves reshape and remodel the architecture and function of their extracellular matrices. The term tumor microenvironment is a wide umbrella consisting of stromal cells such as fibroblasts and endothelial cells and infiltration immune cells including T and B cells, macrophages, and other inflammatory cells (PMNs). These different components of the tumor microenvironment could have stimulatory and inhibitory effects on tumor progression by regulating the gene expression repertoire within the tumor cells on one hand and the stroma cells on the other. In this volume we have seven contributors who will discuss several different aspects on the cross talk within the tumor microenvironment components leading to the acquisition of the metastatic phenotype. It is our hope that these state-of-the-art studies will shed further light on our understanding of these complicated processes.
Editors and Affiliations
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Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, USA
Menashe Bar-Eli
Bibliographic Information
Book Title: Regulation of Gene Expression in the Tumor Environment
Book Subtitle: Regulation of melanoma progression by the microenvironment: the roles of PAR-1 and PAFR
Editors: Menashe Bar-Eli
Series Title: The Tumor Microenvironment
DOI: https://doi.org/10.1007/978-1-4020-8341-9
Publisher: Springer Dordrecht
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer Science+Business Media B.V. 2008
Hardcover ISBN: 978-1-4020-8340-2Published: 04 August 2008
Softcover ISBN: 978-90-481-7849-0Published: 30 November 2010
eBook ISBN: 978-1-4020-8341-9Published: 25 August 2008
Edition Number: 1
Number of Pages: X, 148
Topics: Cancer Research, Oncology, Cell Biology