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One of the most exciting areas of cancer research now is the development of agents which can target signal transduction pathways that are activated inappropriately in malignant cells. The understanding of the molecular abnormalities which distinguish malignant cells from their normal counterparts has grown tremendously. This volume summarizes the current research on the role that signal transduction pathways play in the pathogenesis of cancer and how this knowledge may be used to develop the next generation of more effective and less toxic anticancer agents. Series Editor comments: "The biologic behavior of both normal and cancer cells is determined by critical signal transduction pathways. This text provides a comprehensive review of the field. Leading investigators discuss key molecules that may prove to be important diagnostic and/or therapeutic targets."
Receptors. 1. Growth, Survival and Migration: The Trek to Cancer; J.B. Rubin, R.A. Segal. 2. The Role of Growth Factor Signaling in Malignancy; R.S. Herbst, et al. 3. TGF-beta Signaling Alterations in Cancer; Yansong Bian, et al. 4. Notch in Malignancy; D.W. Ball, S.D. Leach. Intracellular Pathways: 5. cAMP Signaling in Cancer Genesis and Treatment; Yoon S. Cho-Chung. 6. P13K/PTEN/Akt Pathway: A Critical Mediator of Oncogenic Signaling; J. Paez, W.R. sellers. 7. Wnt Signaling in Human Cancer; P.J. Morin, A.T. Weeraratna. 8. Ras Signaling, Deregulation of Gene Expression and Oncogenesis; A.S. Ülkü, C.J. Der. 9. Role of the RB Tumor Suppressor in Cancer; L. Yamasaki. Transcription Factors: 10. The Rel/NF-kappaB/IkappaB Signal Transduction Pathway and Cancer; T.D. Gilmore. 11. STAT Signaling in Cancer: Insights into Pathogenesis and Treatment Strategies; D.A. Frank. 12. Steroid Hormone Receptor Signaling in Cancer; Shinta Cheng, S.P. Balk. Cell Death Pathways: 13. Cell Death Signaling in Malignancy; T.F. Burns, W.S. El-Deiry. 14. Ceramide and Sphingosine 1-Phosphate in Anti-Cancer Therapies; D.K. Perry, R.N. Kolesnick. Index