Cancer Metastasis, Molecular and Cellular Mechanisms and Clinical Intervention

1. Front Matter

   Pages i-ix

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2. Metastatic Cascade, Molecular/Cellular Events and New Therapeutic Opportunities

   • Wen G. Jiang, Robert E. Mansel

   Pages 1-17

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3. The Role of Integrin-Mediated Processes in the Biology of Metastasis

   • John F Marshall, Dawn Davies

   Pages 19-54

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4. The Role of Hyaluronan and Its Degradation Products in Tumour Angiogenesis and Metastasis

   • David C. West

   Pages 55-71

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5. The E-Cadherin/Catenin Complex in Invasion: The Role of Ectodomain Shedding

   • Veerle NoË, Erik Bruyneel, Marc Mareel, Marc Bracke

   Pages 73-119

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6. Cancer and Cancer Metastasis-Related Genes

   • Steve Hiscox

   Pages 121-141

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7. Hepatocyte Growth Factor and Met in Tumour Invasion-metastasis: From Mechanisms to Cancer Prevention

   • Kunio Matsumoto, Toshikazu Nakamura

   Pages 143-193

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8. Tight Junctions, a Critical Structure in the Control of Cancer Invasion and Metastasis

   • Wen G. Jiang, Tracey Martin, Iraj Llaffafian, Robert E. Mansel

   Pages 195-213

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9. Bone Marrow Micrometastases Detection and Significance

   • Hemant Singhal, Michael P. Osborne

   Pages 215-224

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10. Polyunsaturated Fatty Acids and Their Role in Cancer Invasion and Metastasis

    • Wen G Jiang, Amanda Redfern, Aldo Eynard, Robert E Mansel

    Pages 225-250

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11. Metastatic Endocrine Cancer

    • Gregory P Sadler, Malcolm H Wheeler

    Pages 251-278

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12. Prostate Cancer

    • Malcolm D Mason

    Pages 279-296

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13. Gastrointestinal Tumours: Cancer Metastasis, Molecular and Cellular Biology

    • L J Fon, C J Corr, P D Carey

    Pages 297-337

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14. Breast Cancer Metastasis

    • Nader Khonji, Dayalan Clarke, Robert E Mansel

    Pages 339-352

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15. The Malignant Lymphomas

    • Christopher H. Poynton

    Pages 353-380

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16. Cancer Metastasis: Biological and Clinical Aspects, Gynaecological Cancer

    • Malcolm Adams, Bharat Jasani

    Pages 381-420

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17. Back Matter

    Pages 421-431

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This book covers the molecular and cellular aspects of cancer metastasis, and discusses the clinical aspect of micro- and macro-metastases, which result in the death of the majority of patients with cancer. The current edition attempts to examine the current status of the basic scientific and clinical research in the area, and is a very useful reference for clinicians, oncologists, and biologists. It is intended for undergraduates as well as postgraduates in the area of medicine, oncology, and cancer biology.

• angiogenesis
• cancer
• lymphoma
• metastasis
• oncology
• prevention
• prostate cancer
• tumor
• surgical oncology

• University of Wales College of Medicine, UK

  Wen G. Jiang, Robert E. Mansel

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