Cancer Cell Lines Part 1

1. Front Matter

   Pages i-x

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2. Sarcomas

   • Beverly A. Teicher

   Pages 1-19

3. Neuroblastoma

   • Carol J. Thiele

   Pages 21-53

4. Ewing’s Sarcoma Family of Tumors

   • Frans van Valen

   Pages 55-85

5. Mesothelioma

   • Marjan A. Versnel

   Pages 87-105

6. Pancreatic Tumors

   • Takeshi Iwamura, Michael A. Hollingsworth

   Pages 107-122

7. Adrenal Cortex Tumors

   • William E. Rainey, James J. Mrotek

   Pages 123-135

8. Thyroid Gland Tumors

   • Thomas Hoelting

   Pages 137-148

9. Pituitary Gland Tumors

   • Leo J. Hofland, Steven W.J. Lamberts

   Pages 149-159

10. Salivary Gland Tumors

    • Mitsunobu Sato

    Pages 161-178

11. Esophageal Cancers

    • Yutaka Shimada

    Pages 179-212

12. Bladder Cancer

    • Ruth Knuechel, John R W Masters

    Pages 213-230

13. Renal Cell Cancer

    • Thomas Ebert, Aristoteles Anastasiadis, Neil H. Bander

    Pages 231-249

14. Skin Cancer (Non-Melanoma)

    • Petra Boukamp

    Pages 251-257

15. Melanoma: The Wistar Melanoma (WM) Cell Lines

    • Mei-Yu Hsu, David E. Elder, Meenhard Herlyn

    Pages 259-274

16. Melanoma: Brussels Melanoma Cell Lines

    • Francis Brasseur

    Pages 275-282

17. Melanoma: The Milan Melanoma Cell Lines

    • Andrea Anichini, Roberta Mortarini, Claudia Vegetti, Alessandra Molla, Alessandra Borri, Giorgio Parmiani

    Pages 283-292

18. Back Matter

    Pages 293-293

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Continuous cell lines derived from human cancers are the most widely used resource in laboratory-based cancer research. The first 3 volumes of this series on Human Cell Culture are devoted to these cancer cell lines. The chapters in these first 3 volumes have a common aim. Their purpose is to address 3 questions of fundamental importance to the relevance of human cancer cell lines as model systems of each type of cancer: 1. Do the cell lines available accurately represent the clinical presentation? 2. Do the cell lines accurately represent the histopathology of the original tumors? 3. Do the cell lines accurately represent the molecular genetics of this type of cancer? The cancer cell lines available are derived, in most cases, from the more aggressive and advanced cancers. There are few cell lines derived from low grade organ-confined cancers. This gap can be filled with conditionally immortalized human cancer cell lines. We do not know why the success rate for establishing cell lines is so low for some types of cancer and so high for others. The histopathology of the tumor of origin and the extent to which the derived cell line retains the differentiated features of that tumor are critical. The concept that a single cell line derived from a tumor at a particular site is representative of tumors at that site is naïve and misleading.

• biology
• cancer
• cancer research
• cell
• cell culture
• cell lines
• melanoma
• mesothelioma
• tumors

• University College London, London, UK

  John R. W. Masters

• Dept. of Bioengineering, University of California, San Diego, USA

  Bernhard Palsson

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