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Biomedical Sciences - Cancer Research | Pancreatic Cancer

Pancreatic Cancer

Neoptolemos, J.P., Urrutia, R., Abbruzzese, J., Büchler, M.W. (Eds.)

2010, LVIII, 1390 p. In 2 volumes, not available separately.

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American Pancreatic Association
  • The only Major Reference Work entirely devoted to pancreatic cancer
  • The contributing authors are the very best in their respective fields
  • Soon to be the reference of choice among clinicians, pathologists, and basic scientists who now struggle to keep abreast of this complex and rapidly growing field

Worldwide, there are an estimated 232, 000 new cases of pancreatic cancer annually. In the United States, it is the fourth leading cause of cancer death, and approximately 30,000 people die of pancreatic cancer each year. The disease is difficult to diagnose in its early stages, and most patients have incurable disease by the time they present with symptoms. The overall 5-year survival rate for this disease is less than 5%.

In organizing this handbook, Dr. Neoptolemos and his co-editors will produce a distinguished Major Reference Work devoted to pancreatic cancer. This handbook will have widespread appeal among clinicians, pathologists and basic scientists who are now struggling to understand this complex and rapidly expanding field.

Because of the recent and vast growth in both the clinical and scientific research being done in pancreatic cancer (there is currently an unprecedented investment by academia and industry in this field), each researcher’s knowledge of other specialty areas outside his or her own is now often quite limited. The aim of this book is to place these the tangible advances—those that are indispensable to all working on pancreatic cancer—readily at hand. The book will focus on advances that will not become dated, and the editors will choose authors who are the very best in each area.

Content Level » Research

Related subjects » Cancer Research - Internal Medicine - Oncology & Hematology

Table of contents / Sample pages 

Section One: The Nature of Pancreatic Cancer


  1. Epidemiology: world overview, risk factors, prospects for prevention
  2. Development and structure of pancreas
  3. Pathologic classification and biological behaviour of pancreatic neoplasia
  4. Developmental molecular biology of the pancreas
  5. Molecular pathology of precursor lesions of pancreatic cancer, pancreatic intraepithelial neoplasia (PanIN), intraductal papillary mucinous neoplasm (IPMN), and mucinous cystic neoplasm (MCN)
  6. Epigenetics: its fundamentals and applications to a revised comprehensive progression model for pancreatic cancer
  7. Molecular pathology of pancreatic neuroendocrine tumours MEN-1: gastrinomas, insulinoma, Non-Functioning Tumours, VIPoma, glucagonoma, Von Hippel-Lindau, Neurofibromatosis
  8. Sporadic neuroendocrine pancreatic tumours
  9. Molecular pathology of non-pancreatic cancer lesions: Ampullary cancer, intra-pancreatic bile duct cancer, and duodenal cancer
  10. Miscellaneous non-pancreatic non-endocrine tumours
  11. Novel molecular relationships between chronic pancreatitis and cancer
  12. Pancreatic cancer stem cells
  13. Cell cycle control: signalling pathways in pancreatic pathogenesis
  14. Apoptosis: signalling pathways in pancreatic pathogenesis
  15. EGFR: signalling pathways in pancreatic pathogenesis Pl3, Akt, lKK, Ras, Raf, MAPKK, ERK
  16. Hedgehog: signalling pathways in pancreatic pathogenesis
  17. Smad4/TGF-ß pathway: signalling pathways in pancreatic pathogenesis
  18. Notch signalling in pancreatic morphogenesis and pancreatic cancer
  19. Molecular characterization of pancreatic cell lines
  20. Mouse models of exocrine pancreatic cancer
  21. Principles and applications of microarray gene expression in pancreatic cancer
  22. Principles and applications of proteomics in pancreatic cancer
  23. Tumour-stromal interaction: invasion and metastases
  24. Genetic susceptibility, high risk groups, chronic and hereditary pancreatitis, familial pancreatic cancer syndromes
  25. Inherited endocrine pancreatic tumors associated with Multiple Endocrine Neoplasia Type 1 Von-Hippel-Lindau Syndrome, and Neurofibromatosis Type 1

    Section Two: Clinical Management of Pancreatic Cancer

  27. Clinical decision making in pancreatic cancer
  28. Paraneoplastic syndromes
  29. Diagnostic and therapeutic response markers
  30. CT and fusion PET-CT Diagnosis, staging, and follow-up
  31. MRI and MRCP: diagnosis and staging of pancreatic cancer
  32. EUS Diagnosis and staging
  33. Laparoscopy and laparoscopic ultrasound: diagnosis and staging
  34. Overview of palliative management for pancreatic cancer
  35. Endoscopy.
  36. Interventional radiology
  37. Role of palliative surgery in advanced pancreatic cancer
  38. Chemotherapy for advanced pancreatic cancer
  39. Developments in chemoradiation in advanced pancreatic cancer
  40. Surgical resection for pancreatic cancer
  41. Role of venous resection in pancreatic cancer surgery
  42. Pathological reporting and staging following resection
  43. Japanese Pancreas Society staging for pancreatic cancer
  44. Adjuvant chemotherapy in pancreatic cancer
  45. Case for adjuvant chemoradiation therapy for pancreatic cancer
  46. Case for neoadjuvant treatment in pancreatic cancer
  47. Borderline resectable disease
  48. Management of cystic neoplasms serous cystic neoplasms mucinous, cystic neoplasms, intraductal paillary mucinous neoplasms
  49. Laparoscopic surgery for pancreatic neoplasm
  50. Modern Japanese approach to pancreas cancer

    Section Three: New Directions

  52. Development of novel biomarkers
  53. Inherited genetics of pancreatic cancer and secondary screening
  54. Gene therapy for pancreatic cancer
  55. Vaccine therapy and immunotherapy
  56. Emerging targets in pancreatic cancer

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