Over the past few decades, a great many laboratories have focused on the identification of novel tumor antigens that would be potential targets for tumor diagnostics and therapeutics. In spite of important findings in the field, the urgent need for the development of early tumor diagnosis and effective anti-tumor therapies remains.
This work intends to provide a relatively broad audience with a novel approach for the development of cancer diagnostics and targeted therapeutics, based on recently proved hypotheses. It provides comprehensive coverage of the most important aspects of a selected domain of tumor immunology, namely the characteristics and potential capacity of the tumor infiltrating B lymphocytes.
Chapter 1. Tumor infiltrating T lymphocytes: Brief summary about the characteristics and role of tumor infiltrating T lymphocytes.
Chapter 2. Tumor infiltrating B lymphocytes: Characteristics, potential capacity and role of tumor infiltrating B lymphocytes.
Chapter 3. B lymphocytes in different solid tumors: Melanomas, breast carcinomas, ovarian carcinomas, neuroblastoma
Chapter 4. Results of immunoglobulin repertoire analysis: Fetal and adult normal B cells compared to B cells from tumor tissues.
Chapter 5. Potential capacity of natural human antibodies for therapeutic approaches
Chapter 6. Potential capacity of autoantibodies for therapeutic approaches
Chapter 7. Potential capacity, benefits and drawbacks of different antibody fragments for therapeutic approaches
Chapter 8. Methodological arsenal of antibody engineering and biotechnology for developing novel immunoconjugates for diagnostics and therapeutics.
Chapter 9. The secret of tumor infiltrating lymphocytes: novel tumor-specific target antigens revealed.
Chapter 10. The "sleeping beauty" might be awaked: A special family of tumor associated molecules, the gangliosides.
Chapter 11. Achievements and future prospects for novel tumor diagnostics and therapeutics
Chapter 12. The benefits of targeted therapeutics to defeat cancer.